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Xanomeline wash-resistantly bound to presynaptic M2 and M4 muscarinic receptors decreases the evoked release of acetylcholine
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SYSNO ASEP 0090827 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title Xanomeline wash-resistantly bound to presynaptic M2 and M4 muscarinic receptors decreases the evoked release of acetylcholine Title Xanomelin neodmyvatelně navázaný na presynaptické muskarinové M2 a M4 receptory snižuje evokované uvolňování acetylcholinu Author(s) Machová, Eva (FGU-C)
Jakubík, Jan (FGU-C) RID, ORCID
El-Fakahany, E. E. (US)
Doležal, Vladimír (FGU-C) RID, ORCIDSource Title Journal of Neurochemistry. - : Wiley - ISSN 0022-3042
Roč. 101, Suppl.1 (2007), s. 52-53Number of pages 2 s. Action ESN - meeting /17./ - Conference on Advances in Molecular Mechanims and Disorders /3./ Event date 19.05.2007-22.05.2007 VEvent location Salamanca Country ES - Spain Event type EUR Language eng - English Country US - United States Keywords cpo1 ; xanomeline ; muscarinic receptor Subject RIV FH - Neurology R&D Projects LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA305/05/0452 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) Annotation Our data demonstrate that xanomeline functions as wash-resistant agonist of M2 and M4 muscarinic receptors in rat brain cortex and striatum, respectively. Orthosteric binding site is not necessary for wash-resistant binding but for effect of xanomeline Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2008
Number of the records: 1