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Immune escape phenotype of HPV16-associated tumours: MHC class I expression changes during progression and therapy
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SYSNO ASEP 0024562 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Immune escape phenotype of HPV16-associated tumours: MHC class I expression changes during progression and therapy Title Fenotyp imunitního úniku nádorů vyvolaných HPV16: exprese MHC 1. třídy se během nádorové progrese a léčby mění Author(s) Mikyšková, Romana (UMG-J) RID
Bubeník, Jan (UMG-J)
Vonka, V. (CZ)
Šmahel, M. (CZ)
Indrová, Marie (UMG-J) RID
Bieblová, Jana (UMG-J)
Šímová, Jana (UMG-J) RID
Jandlová, Táňa (UMG-J)Source Title International Journal of Oncology. - : Spandidos Publications - ISSN 1019-6439
Roč. 26, č. 2 (2005), s. 521-527Number of pages 7 s. Language eng - English Country GR - Greece Keywords HPV16 ; MHC class I- tumour cells ; CTLs Subject RIV EC - Immunology R&D Projects NC7148 GA MZd - Ministry of Health (MZ) NR8004 GA MZd - Ministry of Health (MZ) NR7807 GA MZd - Ministry of Health (MZ) GA301/04/0492 GA ČR - Czech Science Foundation (CSF) IAA5052203 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z5052915 - UMG-J Annotation Experiments were designed to examine whether the immune escape phenotype of HPV16-associated tumours is stable or whether the MHC class I expression can change during tumour progression and therapy. It has been found that temporary growth of MHC class I- tumours in syngeneic mice can lead to upregulation of the low MHC class I expression during radiotherapy and in tumour recurrences after surgery. If confirmed also with other tumour types and in human tumour systems, the upregulation of MHC class I molecule expression may have important implications in the development of immunotherapeutic strategies. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2006
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