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Immunotherapeutic efficacy of vaccines generated by fusion of dendritic cells and HPV16-associated tumour cells
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SYSNO ASEP 0021918 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Immunotherapeutic efficacy of vaccines generated by fusion of dendritic cells and HPV16-associated tumour cells Title Imunoterapeutická účinnost vakcín připravených fúzí dendritických buněk s buňkami nádorů vyvolaných HPV16 Author(s) Šímová, Jana (UMG-J) RID
Bubeník, Jan (UMG-J)
Bieblová, Jana (UMG-J)
Indrová, Marie (UMG-J) RID
Jandlová, Táňa (UMG-J)Source Title Folia Biologica. - : Univerzita Karlova v Praze - ISSN 0015-5500
Roč. 51, č. 1 (2005), s. 19-24Number of pages 6 s. Language eng - English Country CZ - Czech Republic Keywords HPV16 ; DC-tumour hybrids ; immunotherapy Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA5052203 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA301/04/0492 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520514 - UMG-J (2005-2011) Annotation Utilization of vaccines generated by fusion of dendritic cells and tumour cells is a promising approach to tumour immunotherapy. We have examined the therapeutic efficacy of vaccines generated by fusion of HPV16-associated tumour cells TC-1 with syngeneic and allogeneic dendritic cells. Locally administered hybrid cells generated by fusion of MHC class I+ TC-1 cells and syngeneic DC inhibited the growth of MHC class I+ TC-1 tumours, but not the growth of MHC class I- TC-1/A9-derived tumours. The growth of TC-1 tumours was also inhibited by hybrids generated by fusion of TC-1 cells and allogeneic DC. The therapeutic efficacy was enhanced by co-administration of the vaccine with synthetic immunostimulatory ODN CpG 1826. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2006
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