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Stereoselective Hydrogenation of Methylacetoacetate in Microfluidic Chip Reactor in Presence of [N8222][Tf2N] Ionic Liquid.

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    0486326 - ÚCHP 2018 DE eng C - Conference Paper (international conference)
    Stavárek, Petr - Klusoň, Petr - Hejda, Stanislav - Pěnkavová, Věra - Vychodilová, Hana - Bendová, Magdalena
    Stereoselective Hydrogenation of Methylacetoacetate in Microfluidic Chip Reactor in Presence of [N8222][Tf2N] Ionic Liquid.
    Book of Abstracts. -, 2017, s. 50. ISBN N.
    [Conference Advancing Chemical Synthesis through Automation, Processes and Thinking, Beilstein Organic Chemistry Symposium 2017. Potsdam (DE), 26.09.2017-28.09.2017]
    R&D Projects: GA ČR GA15-04790S
    Institutional support: RVO:67985858
    Keywords : hydrogenation * ionic liquids * microreactors
    Subject RIV: CI - Industrial Chemistry, Chemical Engineering
    OBOR OECD: Chemical process engineering

    In this study, we focused on the application of a microfluidic chip reactor to the stereoselective hydrogenation of achiral methylacetoacetate (MAA) to isomeric (R)-(+) or (S)-(-)-methyl-3-hydroxybutanoate (MHB) over a chiral ([RuCl((R)-BINAP)(p-cymene)]Cl) complex immobilized in the mixed [N8222][Tf2N]/methanol/water solvent phase. A presence of ionic liquid (quarternary ammonium salt) has a potential for an easy separation of this catalyst via its pseudo-immobilization. The reaction has been successfully carried out in such an arrangement with a very high conversion of MAA (above 97%) also reaching a very high enantioselectivity (above 99%) towards the (R)-(+)-methyl-3-hydroxybutanoate isomer.
    Permanent Link: http://hdl.handle.net/11104/0281171
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