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Novel Trypanosomatid-Bacterium Association: Evolution of Endosymbiosis in Action

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    0469000 - BC 2017 RIV US eng J - Journal Article
    Kostygov, A.Y. - Dobáková, Eva - Grybchuk-Ieremenko, A. - Váhala, D. - Maslov, D. A. - Votýpka, Jan - Lukeš, Julius - Yurchenko, V.
    Novel Trypanosomatid-Bacterium Association: Evolution of Endosymbiosis in Action.
    mBio. Roč. 7, č. 2 (2016), č. článku e01985-15. ISSN 2150-7511
    R&D Projects: GA ČR(CZ) GA14-23986S
    EU Projects: European Commission(XE) 316304 - MODBIOLIN
    Grant - others:EU COST Action CM1307
    Institutional support: RVO:60077344
    Keywords : leader rna gene * insect trypanosomatids * monoxenous trypanosomatids * neotropical heteroptera * Trichomonas vaginalis * phylogenetic analysis
    Subject RIV: EB - Genetics ; Molecular Biology
    Impact factor: 6.956, year: 2016

    We describe a novel symbiotic association between a kinetoplastid protist, Novymonas esmeraldas gen. nov., sp. nov., and an intracytoplasmic bacterium, "Candidatus Pandoraea novymonadis" sp. nov., discovered as a result of a broad-scale survey of insect trypanosomatid biodiversity in Ecuador. We characterize this association by describing the morphology of both organisms, as well as their interactions, and by establishing their phylogenetic affinities. Importantly, neither partner is closely related to other known organisms previously implicated in eukaryote-bacterial symbiosis. This symbiotic association seems to be relatively recent, as the host does not exert a stringent control over the number of bacteria harbored in its cytoplasm. We argue that this unique relationship may represent a suitable model for studying the initial stages of establishment of endosymbiosis between a single-cellular eukaryote and a prokaryote. Based on phylogenetic analyses, Novymonas could be considered a proxy for the insect-only ancestor of the dixenous genus Leishmania and shed light on the origin of the two-host life cycle within the subfamily Leishmaniinae.
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