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Expression and cellular localization of hepcidin mRNA and protein in normal rat brain

  1. 1. 0450356 - UEM-P 2016 RIV GB eng J - Journal Article
    Raha-Chowdhury, R. - Raha, A.A. - Forostyak, Serhiy - Zhao, J.W. - Stott, S.R.W. - Bomford, A.
    Expression and cellular localization of hepcidin mRNA and protein in normal rat brain.
    BMC Neuroscience. Roč. 16, APR 21 (2015), s. 24. ISSN 1471-2202
    Institutional support: RVO:68378041
    Keywords : hepcidin * ferroportin * defensin * inflammatory cytokines * brain iron homeostasis * blood brain barrier * pericytes * sub-ventricular zone * neurogenesis
    Subject RIV: FH - Neurology
    Impact factor: 2.304, year: 2015

    Hepcidin is a peptide hormone belonging to the defensin family of cationic antimicrobial molecule that has an essential role in systemic iron homeostasis. However, not all hepcidin in the brain is transcribed in situ and may originate in part outside the brain. The properties of hepcidin as a cationic peptide hormone are reflected in the finding of hepcidin in the walls of blood vessels and in pericytes and glia, cells that may be involved in transporting the peptide into brain interstitium
    Permanent Link: http://hdl.handle.net/11104/0251885