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Contribution of Ca2+-Dependent Cl- Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing

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    0428048 - FGU-C 2015 RIV US eng J - Journal Article
    Líšková, Silvia - Petrová, M. - Karen, Petr - Behuliak, Michal - Zicha, Josef
    Contribution of Ca2+-Dependent Cl- Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing.
    BioMed Research International. Roč. 2014, č. 2014 (2014), s. 289361. ISSN 2314-6133
    R&D Projects: GA ČR(CZ) GAP304/12/0259
    Institutional support: RVO:67985823
    Keywords : calcium-dependent chloride channels * endothelium-derived contracting factor * ageing
    Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
    Impact factor: 1.579, year: 2014

    The activation of calcium-dependent chloride channels during norepinephrine-induced contraction of vascular smooth muscle was suggested to depolarize cell membrane and to increase calcium entry. Hypertension and ageing are associated with altered calcium handling including possible activation of calcium-dependent chloride channels. Our study was aimed to determine calcium -dependent chloride channels contribution to norepinephrine-induced contraction during hypertension and ageing. We have found that contribution of calcium -dependent chloride channels to norepinephrine-induced contraction diminished with age, hypertension development, and/or NO synthesis inhibition
    Permanent Link: http://hdl.handle.net/11104/0233483