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CD36 Protein Influences Myocardial Ca2+ Homeostasis and Phospholipid Metabolism CONDUCTION ANOMALIES IN CD36-DEFICIENT MICE DURING FASTING

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    0387525 - FGU-C 2013 RIV US eng J - Journal Article
    Pietka, T. A. - Sulkin, M.S. - Kuda, Ondřej - Wang, W. - Zhou, D. - Yamada, K. A. - Yang, K. - Su, X. - Gross, R. W. - Nerbonne, J. M. - Efimov, I. R. - Abumrad, N. A.
    CD36 Protein Influences Myocardial Ca2+ Homeostasis and Phospholipid Metabolism CONDUCTION ANOMALIES IN CD36-DEFICIENT MICE DURING FASTING.
    Journal of Biological Chemistry. Roč. 287, č. 46 (2012), s. 38901-38912. ISSN 0021-9258
    Institutional support: RVO:67985823
    Keywords : calcium * cyclic AMP (cAMP) * heart * phospholipid * phospholipid metabolism * polyunsaturated fatty acids * CD36 deficiency * SERCA2a * sudden death
    Subject RIV: ED - Physiology
    Impact factor: 4.651, year: 2012

    Myocardial function during fasting was examined in wild-type and CD36−/− mice. CD36−/− mice have abnormalities of myocardial Ca2+, phospholipid composition, and cAMP levels and manifest electrical anomalies during fasting. Conclusion: CD36 influences myocardial adaptation by impacting Ca2+ dynamics and phospholipid metabolism. Significance: Inter-dependence of lipid metabolism and Ca2+ homeostasis can contribute to cardiac dysfunction during metabolic stress
    Permanent Link: http://hdl.handle.net/11104/0220284