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Effect of tetrabrombisphenol A on induction of apoptosis in the testes and changes in expression of selected testicular genes in CD1 mice

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    0380136 - BTÚ 2013 RIV US eng J - Journal Article
    Žatecká, Eva - Děd, Lukáš - Elzeinová, Fatima - Kubátová, Alena - Dorosh, Andriy - Margaryan, Hasmik - Dostálová, Pavla - Pěknicová, Jana
    Effect of tetrabrombisphenol A on induction of apoptosis in the testes and changes in expression of selected testicular genes in CD1 mice.
    Reproductive Toxicology. Roč. 35, č. 1 (2013), s. 32-39. ISSN 0890-6238
    R&D Projects: GA MŠk 2B06151; GA MŠk 1M06011; GA MZd NS10009; GA ČR GA523/09/1793
    Grant - others:GA ČR(CZ) GD524/05/H536
    Program:GD
    Institutional research plan: CEZ:AV0Z50520701
    Keywords : tetrabromobisphenol A * fertility * reproductive parameters * spermatogenesis * histopathology of testes * apoptosis * gene expression
    Subject RIV: EB - Genetics ; Molecular Biology
    Impact factor: 2.771, year: 2013

    Tetrabromobisphenol A (TBBPA) is a substance widely used in industry as a flame retardant. TBBPA was found in the environment and was detected even in the human body. The effect of this chemical was observed in different cell lines in vitro and it is supposed that TBBPA may affect various hormonal systems in vivo. In this study we examined the effect of TBBPA on the reproductive parameters of two generations of outbred mice in vivo. Experimental and control animals of F1 generation were bred in various conditions to enable evaluation of the possible trans-generational effect. An increased incidence of apoptosis in the testes and changes in the morphometry of seminiferous tubules was detected in the experimental animals. In addition, changes in the expression pattern of selected genes encoding proteins that play an important role during spermatogenesis were observed. In contrast, sperm quality and reproduction were not affected by TBBPA.
    Permanent Link: http://hdl.handle.net/11104/0210928
     
Number of the records: 1