Number of the records: 1

Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies

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    0369728 - MBU-M 2012 RIV US eng J - Journal Article
    Váchová, Libuše - Šťovíček, V. - Hlaváček, Otakar - Chernyavskiy, Oleksandr - Štěpánek, L. - Kubínová, Lucie - Palková, Z.
    Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies.
    Journal of Cell Biology. Roč. 194, č. 5 (2011), s. 679-687 ISSN 0021-9525
    R&D Projects: GA ČR GA204/08/0718; GA MŠk(CZ) LC531; GA MŠk(CZ) LC06063
    Institutional research plan: CEZ:AV0Z50200510; CEZ:AV0Z50110509
    Keywords : CANDIDA-ALBICANS BIOFILMS * SACCHAROMYCES-CEREVISIAE * ABC TRANSPORTERS
    Subject RIV: EE - Microbiology, Virology
    Impact factor: 10.264, year: 2011

    The molecular mechanisms underlying the spatiotemporal development and environmental resistance of biofilms and colonies remain largely unknown. We show that a biofilm yeast colony is a finely tuned, complex ’multicellular organism‘, in which specialized cells jointly execute multiple protection strategies. These include a Pdr1p-regulated mechanism whereby multidrug-resistance transporters Pdr5p and Snq2p expel external compounds solely within the surface cell layers, as well as developmentally regulated production by internal cells of a selectively permeable extracellular matrix. The two mechanisms act in concert during colony development, allowing growth of new cell generations in a well protected, internal cavity of the colony. Colony architecture is strengthened by intercellular fiber connections
    Permanent Link: http://hdl.handle.net/11104/0203729