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The inhibition of fat cell proliferation by fatty acids in dietary obese mice

  1. 1. 0364484 - FGU-C 2012 RIV GB eng J - Journal Article
    Hensler, Michal - Bardová, Kristina - Macek Jílková, Zuzana - Wahli, W. - Meztger, D. - Chambon, P. - Kopecký, Jan - Flachs, Pavel
    The inhibition of fat cell proliferation by fatty acids in dietary obese mice.
    Lipids in Health and Disease. Roč. 10, - (2011), s. 128. ISSN 1476-511X
    R&D Projects: GA ČR(CZ) GAP301/11/0226; GA ČR(CZ) GD305/08/H037
    Institutional research plan: CEZ:AV0Z50110509
    Keywords : DHA and EPA * fish oil * fat cell turnover
    Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
    Impact factor: 2.170, year: 2011

    A model of inducible and reversible lipoatrophy (aP2-Cre-ERT2 PPARγL2/L2 mice) was used, in which the death of mature adipocytes could be achieved by a selective ablation of peroxisome proliferator-activated receptor γ in response to i.p. injection of tamoxifen. The results document that dietary LC n-3 PUFA could decrease adiposity in obese mice by a mechanism, which depends on counteraction of both, differentiation and proliferation of adipose cells. These results also support the notion that adiposity is closely linked to the control of fat cell turnover and that mechanisms could exist, which control fat cell proliferation independent of energy balance
    Permanent Link: http://hdl.handle.net/11104/0199960