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Sigma factors and promoters in Corynebacterium glutamicum

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    0360900 - MBÚ 2012 RIV NL eng J - Journal Article
    Pátek, Miroslav - Nešvera, Jan
    Sigma factors and promoters in Corynebacterium glutamicum.
    Journal of Biotechnology. Roč. 154, 2-3 (2011), s. 101-113. ISSN 0168-1656
    R&D Projects: GA ČR GC204/09/J015
    Institutional research plan: CEZ:AV0Z50200510
    Keywords : Corynebacterium glutamicum * Sigma factors * Promoters
    Subject RIV: EE - Microbiology, Virology
    Impact factor: 3.045, year: 2011

    Corynebacterium glutamicum genome codes for 7 sigma subunits (factors) of RNA polymerase (RNAP). Each sigma factor is responsible for recognizing promoters of genes belonging to a regulon (sigmulon) involved in specific functions of the cell. Promoters of individual classes recognized by different sigma factors are compiled and the respective consensus sequences of their key recognition motifs (-35 and -10 regions) are derived. In a number of genes, two or more promoters controlled by the same or different sigma factors were discovered. These multiple, overlapping or dual promoters contribute to a complex gene transcription control mechanisms that integrate internal and external signals and tune gene expression in cells as required by environmental and physiological conditions
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