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Voltammetric determination of anticancer drug flutamide at screen-printed carbon electrodes

  1. 1. 0359971 - UFCH-W 2012 RIV CZ eng C - Conference Paper (international conference)
    Vyskočil, V. - Navrátil, Tomáš - Barek, J.
    Voltammetric determination of anticancer drug flutamide at screen-printed carbon electrodes.
    Sborník přednášek. XXXI. Moderní elektrochemické metody. Ústí nad Labem: BEST servis, 2011 - (Navrátil, T.; Barek, J.), s. 190-194. ISBN 978-80-254-9634-3.
    [Moderní elektrochemické metody /31./. Jetřichovice (CZ), 23.05.2011-27.05.2011]
    R&D Projects: GA AV ČR IAA400400806; GA ČR GAP206/11/1638
    Institutional research plan: CEZ:AV0Z40400503
    Keywords : creatine * screen-printed carbon electrodes * flutamide
    Subject RIV: CG - Electrochemistry

    Flutamide, 4-nitro-3-trifluoromethyl-isobutylanilide, is the active component of a synthetic nonsteroidal antiandrogen drug, which is commonly used in the treatment of advanced prostate cancer. In this contribution, optimum conditions have been found vor voltammetric determination of flutamide by DC voltammetry (DCV) and differential pulse voltammetry (DPV) at screen-printed carbon electrodes (SPCEs). Under optimum conditions (Britton-Robinson buffer pH 7.0 - methanol (9:1)), linear calibration curves were measure with limits of quantification 6x10(-7) molL(-1) and 8x10(-7) molL(-1) for DCV at SPCEs, respectively. The newly developed methods were successfully applied to the determination of the drug in pharmaceutical formulation Apo-Flutamide (Eulexin tablets).
    Permanent Link: http://hdl.handle.net/11104/0197638