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MMP19 is upregulated during melanoma progression and increases invasion of melanoma cells

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    0346783 - ÚMG 2011 RIV US eng J - Journal Article
    Muller, M. - Beck, Inken - Gadesmann, J. - Karschuk, N. - Paschen, A. - Proksch, E. - Djonov, V. - Reiss, K. - Sedláček, Radislav
    MMP19 is upregulated during melanoma progression and increases invasion of melanoma cells.
    Modern Pathology. Roč. 23, č. 4 (2010), s. 511-521. ISSN 0893-3952
    Institutional research plan: CEZ:AV0Z50520514
    Keywords : melanoma * invasion * matrix metalloproteinase
    Subject RIV: EB - Genetics ; Molecular Biology
    Impact factor: 4.176, year: 2010

    In this study, we analysed the expression of MMP19 in the course of melanoma progression. Although MMP19 was absent in melanocytes and melanoma cells of early stages of melanoma development, its expression was strongly upregulated in the neighbouring keratinocytes. In contrast to early stages, MMP19 was upregulated during the vertical growth phase of melanoma and in metastases. The upregulation of MMP19 in melanoma of Clark levels IV and V correlates with that of MMP2 and E-cadherin. Melanoma cell lines with low expression of MMP19 exhibited increased adhesion to various substrates and lower migration in comparison with the cell line with higher expression of MMP19. Moreover, ectopic expression of MMP19 could restore the migratory capacity of melanoma cells with low endogenous level of MMP19. These results suggest that the increase of MMP19 expression hallmarks the progression of cutaneous melanoma and might augment melanoma growth by promoting the invasion of tumour cells.
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