Expression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study

0343468 - ÚI 2011 RIV US eng J - Journal Article
Vrajová, M. - Šťastný, František - Horáček, J. - Lochman, J. - Šerý, O. - Peková, S. - Klaschka, Jan - Höschl, C.
Expression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study.
Neurochemical Research. Roč. 35, č. 7 (2010), s. 994-1002. ISSN 0364-3190. E-ISSN 1573-6903
Grant - others:GA MZd(CZ) NR9324
Institutional research plan: CEZ:AV0Z50110509; CEZ:AV0Z10300504
Keywords : schizophrenia * hippocampus * GluN1 subunit of NMDA receptor * splice variants * laterality
Subject RIV: FL - Psychiatry, Sexuology
Impact factor: 2.608, year: 2010

There is accumulating evidence that disturbances in N-methyl-D-aspartate receptor (NMDA-R) functioning are associated with the pathogenesis of schizophrenia. To assess actual changes in the expression of the GluN1 subunit and its isoforms, we measured absolute differences in the levels of mRNA/protein for panGluN1 (eight isoforms altogether) as well as the mRNA individual isoforms in the postmortem left/right hippocampus of patients with schizophrenia in comparison with non-psychiatric subjects. Our results suggest that NMDA-R hypofunction in schizophrenia might be selectively dependent on the dysregulation of GluN1 subunit expression, which exhibits a somewhat different expression in the left/right hippocampus of psychotic patients.
Permanent Link: http://hdl.handle.net/11104/0185943