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Energetics, conformation, and recognition of DNA duplexes modified by methylated analogues of [PtCl(dien)]+
- 1.0327307 - BFÚ 2010 RIV DE eng J - Journal Article
Nováková, Olga - Malina, Jaroslav - Kašpárková, Jana - Halámiková, Anna - Bernard, Vladan - Intini, F. - Natile, G. - Brabec, Viktor
Energetics, conformation, and recognition of DNA duplexes modified by methylated analogues of [PtCl(dien)]+.
[Energetika, konformace a rozpoznání duplexů DNA modifikovaných methylovanými analogy [PtCl(dien)]+.]
Chemistry - A European Journal. Roč. 15, č. 25 (2009), s. 6211-6221. ISSN 0947-6539. E-ISSN 1521-3765
R&D Projects: GA MŠMT(CZ) LC06030; GA MŠMT(CZ) ME08017; GA MŠMT(CZ) OC08003; GA AV ČR(CZ) 1QS500040581; GA AV ČR(CZ) KAN200200651; GA AV ČR(CZ) IAA400040803; GA ČR(CZ) GA203/06/1239
Grant - others:GA MŠk(CZ) OC09018
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : platinum complexes * DNA * polymerization
Subject RIV: BO - Biophysics
Impact factor: 5.382, year: 2009
Goals of this study, performed in cell-free media, were to determine how the modification of DNA duplexes by methylated analogues of [Pt(NO3)(dien)]+ affects their energetics and how the alterations of this biophysical parameter are reflected by the recognition of these duplexes by DNA polymerases and the DNA repair system.
Cílem této studie bylo zjistit, jak modifikace DNA methylovanými analogy dienplatiny ovlivňuje její termodynamiku a jakým způsobem jsou tyto změny reflektovány DNA polymerázami a DNA reparačním systémem.
Permanent Link: http://hdl.handle.net/11104/0174152
Number of the records: 1