Number of the records: 1  

The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei

  1. 1.
    0318325 - BC-A 2009 RIV NL eng J - Journal Article
    Long, Shaojun - Vávrová, Zuzana - Lukeš, Julius
    The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei.
    [Import a funkce rozsivkového a rostlinného frataxinu v mitochondrii Trypanosoma brucei.]
    Molecular and Biochemical Parasitology. Roč. 162, č. 1 (2008), s. 100-104. ISSN 0166-6851
    R&D Projects: GA AV ČR IAA500960705; GA MŠk LC07032; GA MŠk 2B06129; GA ČR GA204/06/1558
    Institutional research plan: CEZ:AV0Z60220518
    Keywords : frataxin * mitochondrion * Trypanosoma * diatom * evolutionary conservativeness * import
    Subject RIV: EB - Genetics ; Molecular Biology
    Impact factor: 2.951, year: 2008

    Frataxin is a conserved mitochondrial protein, almost universally present in prokaryotes and eukaryotes, where it is implicated in Fe-S cluster assembly and several other processes. Here we show that frataxins from the diatom Thalassiosira pseudonana and the plant Arabidopsis thaliana are efficiently targeted and processed in the mitochondrion of the evolutionary distant excavate kinetoplastid flagellate Trypanosoma brucei. Moreover, both heterologous frataxins are able to rescue a lethal deficiency for T. brucei frataxin.

    Frataxin je konzervovaný mitochondriální protein, všudypřítomný u prokaryot a eukaryot, kde se zúčastňuje tvorby Fe-S klasterů a dalších procesů. V této práci ukazujeme, že frataxin z rozsivky Thalassiosira pseudonana a rostliny Arabidopsis thaliana je efektivně vnášen a upravován v mitochondrii evolučně vzdáleného kinetoplastidového bičíkovce Trypanosoma brucei. Navíc byly oba heterologní frataxiny schopny zachránit smrtelnou deficienci frataxinu v T. brucei.
    Permanent Link: http://hdl.handle.net/11104/0167776