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Local IFN-gamma therapy of HPV16-associated tumours

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    0191581 - UMG-J 20033048 RIV CZ eng J - Journal Article
    Mikyšková, Romana - Bieblová, Jana - Šímová, Jana - Indrová, Marie - Jandlová, Táňa - Vonka, V. - Šmahel, M. - Bubeník, Jan - Mendoza, Luis
    Local IFN-gamma therapy of HPV16-associated tumours.
    Folia Biologica. Roč. 49, č. 1 (2003), s. 26-32. ISSN 0015-5500
    R&D Projects: GA MZd NC7148; GA MZd NC5900; GA ČR GA301/01/0985
    Grant - others:GA CZ(CZ) Liga proti rakovině
    Institutional research plan: CEZ:AV0Z5052915
    Keywords : MHC class I * IFN-gamma * HPV16
    Subject RIV: FD - Oncology ; Hematology
    Impact factor: 0.527, year: 2003

    The paper examines whether peritumoral administration of IFN-gamma can inhibit growth of HPV16-associated, MHC class I- MK16 tumour transplanted in syngeneic mice. Treatment of tumour transplants with IFN-gamma was efficient until the tumours reached a palpable size. Treatment of surgically induced minimal residual tumour disease was moderate, reproducible, but statistically insignificant.
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