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Comparison of various UHMWPE formulations from contemporary total knee replacements before and after accelerated aging
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SYSNO ASEP 0617860 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Comparison of various UHMWPE formulations from contemporary total knee replacements before and after accelerated aging Author(s) Fulín, P. (CZ)
Gajdošová, Veronika (UMCH-V) RID, ORCID
Šloufová, I. (CZ)
Hodan, Jiří (UMCH-V)
Pokorný, D. (CZ)
Šlouf, Miroslav (UMCH-V) RID, ORCIDArticle number 113795 Source Title Materials and Design. - : Elsevier - ISSN 0264-1275
Roč. 252, April (2025)Number of pages 16 s. Language eng - English Country GB - United Kingdom Keywords UHMWPE ; total knee replacement ; accelerated aging Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects NU21-06-00084 GA MZd - Ministry of Health (MZ) Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 001443777000001 EID SCOPUS 86000297173 DOI https://doi.org/10.1016/j.matdes.2025.113795 Annotation We have collected 21 different formulations of ultrahigh molecular weight polyethylene (UHMWPE), which have been employed as liners in contemporary total knee replacements (TKR). The UHMWPE liners were bought from the most important manufacturers on the orthopedic market in the Czech Republic as of 2020. The collected liners represented a broad range of both traditional and modern UHMWPE formulations, which differed by the level of crosslinking, type of thermal treatment, sterilization and/or stabilization. All obtained UHMWPE’s were characterized by multiple methods immediately after purchase and after the accelerated aging in H2O2. The experimental results (oxidative degradation, structure changes, and micromechanical properties) were correlated with manufacturer’s data (crosslinking, thermal treatment, sterilization, and stabilization). The investigated UHMWPE liners exhibited significant differences in their properties, namely in their resistance to long term oxidative degradation. The stiffness-related mechanical properties showed a strong correlation with the overall crystallinity. The crystallinity depended mostly on the oxidative degradation of the UHMWPE liners, while the thermal treatment played a minor role. The highest resistance to oxidation and wear, which promises the best in vivo performance, was found for the crosslinked UHMWPE formulations with biocompatible stabilizers (such as α-tocopherol, which is the key component of vitamin E). Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2026 Electronic address https://www.sciencedirect.com/science/article/pii/S0264127525002151?via%3Dihub
Number of the records: 1