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Microfluidic controlled self-assembly of polylactide (PLA)-based linear and graft copolymers into nanoparticles with diverse morphologies
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SYSNO ASEP 0588500 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Microfluidic controlled self-assembly of polylactide (PLA)-based linear and graft copolymers into nanoparticles with diverse morphologies Author(s) Lukáš Petrova, Svetlana (UMCH-V) ORCID, RID
Sincari, Vladimir (UMCH-V) ORCID, RID
Pavlova, Ewa (UMCH-V) RID
Pokorný, Václav (UMCH-V) RID, ORCID
Lobaz, Volodymyr (UMCH-V) RID, ORCID
Hrubý, Martin (UMCH-V) RID, ORCIDSource Title ACS Polymers Au. - : American Chemical Society
Roč. 4, č. 4 (2024), s. 331-341Number of pages 11 s. Language eng - English Country US - United States Keywords polylactide (PLA)-based copolymers ; microfluidic ; micelles Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects LM2023053 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EH22_008/0004607 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 001237237000001 EID SCOPUS 85195069755 DOI https://doi.org/10.1021/acspolymersau.4c00033 Annotation This study outlines the microfluidic (MF) controlled self-assembly of polylactide (PLA)-based linear and graft copolymers. The PLA-based copolymers (PLA-Cs) were synthesized through a convenient one-pot/one-step ROP/RAFT technique. Three distinct vinyl monomers─triethylene glycol methacrylate (TEGMA), 2-hydroxypropyl methacrylate (HPMA), and N-(2-hydroxypropyl) methacrylamide (HPMAA) were employed to prepare various copolymers: linear thermoresponsive polylactide-b-poly(triethylene glycol methacrylate) (PLA-b-PTEGMA), graft pseudothermoresponsive poly[N-(2-hydroxypropyl)] methacrylate-g-polylactide (PHPMA-g-PLA), and graft amphiphilic poly[N-(2-hydroxypropyl)] methacrylamide-g-polylactide (PHPMAA-g-PLA). The MF technology was utilized for the controlled self-assembly of these PLA-based BCs in a solution, resulting in a range of nanoparticle (NP) morphologies. The thermoresponsive PLA-b-PTEGMA diblock copolymer formed thermodynamically stable micelles (Ms) through kinetically controlled assemblies. Similarly, employing MF channels led to the self-assembly of PHPMA-g-PLA, yielding polymersomes (PSs) with adjustable sizes under the same solution conditions. Conversely, the PHPMAA-g-PLA copolymer generated worm-like particles (Ws). The analysis of resulting nano-objects involves techniques such as transmission electron microscopy, dynamic light scattering investigations (DLS), and small-angle X-ray scattering (SAXS). More specifically, the thermoresponsive behavior of PLA-b-PTEGMA and PHPMA-g-PLA nano-objects is validated through variable-temperature DLS, TEM, and SAXS methods. Furthermore, the study explored the specific interactions between the formed Ms, PSs, and/or Ws with proteins in human blood plasma, utilizing isothermal titration calorimetry. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2025 Electronic address https://pubs.acs.org/doi/10.1021/acspolymersau.4c00033
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