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In vivo and in vitro study of resorbable magnesium wires for medical implants: Mg purity, surface quality, Zn alloying and polymer coating
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SYSNO ASEP 0587722 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title In vivo and in vitro study of resorbable magnesium wires for medical implants: Mg purity, surface quality, Zn alloying and polymer coating Author(s) Tesař, Karel (FZU-D) ORCID
Luňáčková, J. (CZ)
Jex, M. (CZ)
Žaloudková, Margit (USMH-B) RID
Vrbová, R. (CZ)
Bartoš, M. (CZ)
Klein, P. (CZ)
Vištejnová, L. (CZ)
Dušková, J. (CZ)
Filová, Elena (FGU-C) RID, ORCID
Sucharda, Zbyněk (USMH-B)
Steinerová, Marie (FGU-C) ORCID
Habr, Stanislav (FZU-D)
Balík, Karel (USMH-B) RID, ORCID
Singh, A. (JP)Number of authors 15 Source Title Journal of Magnesium and Alloys. - : KeAi Publishing Communications - ISSN 2213-9567
Roč. 12, č. 6 (2024), s. 2472-2488Number of pages 17 s. Language eng - English Country CN - China Keywords magnesium ; resorbable Mg wire ; Mg-Zn implant degradation ; biocompatibility study ; Zn grain boundary segregation Subject RIV BM - Solid Matter Physics ; Magnetism OECD category Biomaterials (as related to medical implants, devices, sensors) Subject RIV - cooperation Institute of Physiology - Biotechnology ; Bionics
Institute of Rock Structure and Mechanics - Biotechnology ; BionicsR&D Projects EH22_008/0004591 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) TP01010055 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) Method of publishing Open access Institutional support FZU-D - RVO:68378271 ; FGU-C - RVO:67985823 ; USMH-B - RVO:67985891 UT WOS 001273472800001 EID SCOPUS 85196953966 DOI https://doi.org/10.1016/j.jma.2024.06.003 Annotation Magnesium is an excellent material in terms of biocompatibility and its corrosion products can serve as an active source for new bone formation. Utilizing low-alloyed Mg-Zn wires can strongly reduce problems with large H2 bubbles and improve the mechanical properties. Acidic pickling and a polymer coating can be effectively used to lower the rate of in vivo degradation. In this work, microstructural, mechanical, and in vitro characterization of 250 µm and 300 µm extruded wires made from ultra-pure Mg, commercially pure Mg, Mg-0.15Zn, Mg-0.4Zn and Mg-1Zn was performed. Additionally, Mg-0.4Zn wires together with a variant coated with a copolymer of l-lactide and ε-caprolactone were tested in vivo on artificially damaged Wistar rat femurs. Based on the observed Mg-induced osteogenesis, polymer-coated Mg wires with a small addition of Zn are a perspective material for bone-support applications, such as cerclage and fixation wires. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2025 Electronic address https://hdl.handle.net/11104/0354828
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