0587672 - FGÚ 2025 RIV GB eng J - Journal Article
Kasperová, B. J. - Mráz, M. - Svoboda, P. - Hlaváček, D. - Kratochvílová, H. - Modos, I. - Vrzáčková, N. - Ivák, P. - Janovská, Petra - Kobets, Tetyana - Mahrík, J. - Riečan, Martin - Steiner Mrázová, Lenka - Stránecký, V. - Netuka, I. - Čajka, Tomáš - Kuda, Ondřej - Melenovský, V. - Štemberková-Hubáčková, S. - Haluzík, M.
Sodium-glucose cotransporter 2 inhibitors induce anti-inflammatory and anti-ferroptotic shift in epicardial adipose tissue of subjects with severe heart failure.
Cardiovascular Diabetology. Roč. 23, č. 1 (2024), č. článku 223. ISSN 1475-2840. E-ISSN 1475-2840
R&D Projects: GA MŠMT(CZ) LX22NPO5104; GA MZd(CZ) NV19-02-00118; GA MŠMT(CZ) EF16_013/0001775
Research Infrastructure: Czech-BioImaging III - 90250
Institutional support: RVO:67985823
Keywords : sodium-glucose cotransporter 2 inhibitors * heart failure * inflammation * adipose tissue * ether lipids
OECD category: Cardiac and Cardiovascular systems
Impact factor: 8.5, year: 2023 ; AIS: 2.188, rok: 2023
Method of publishing: Open access
Result website:
https://doi.org/10.1186/s12933-024-02298-9DOI: https://doi.org/10.1186/s12933-024-02298-9

BackgroundSodium-glucose cotransporter 2 inhibitors (SGLT-2i) are glucose-lowering agents used for the treatment of type 2 diabetes mellitus, which also improve heart failure and decrease the risk of cardiovascular complications. Epicardial adipose tissue (EAT) dysfunction was suggested to contribute to the development of heart failure. We aimed to elucidate a possible role of changes in EAT metabolic and inflammatory profile in the beneficial cardioprotective effects of SGLT-2i in subjects with severe heart failure.Methods26 subjects with severe heart failure, with reduced ejection fraction, treated with SGLT-2i versus 26 subjects without treatment, matched for age (54.0 +/- 2.1 vs. 55.3 +/- 2.1 years, n.s.), body mass index (27.8 +/- 0.9 vs. 28.8 +/- 1.0 kg/m2, n.s.) and left ventricular ejection fraction (20.7 +/- 0.5 vs. 23.2 +/- 1.7%, n.s.), who were scheduled for heart transplantation or mechanical support implantation, were included in the study. A complex metabolomic and gene expression analysis of EAT obtained during surgery was performed.ResultsSGLT-2i ameliorated inflammation, as evidenced by the improved gene expression profile of pro-inflammatory genes in adipose tissue and decreased infiltration of immune cells into EAT. Enrichment of ether lipids with oleic acid noted on metabolomic analysis suggests a reduced disposition to ferroptosis, potentially further contributing to decreased oxidative stress in EAT of SGLT-2i treated subjects.ConclusionsOur results show decreased inflammation in EAT of patients with severe heart failure treated by SGLT-2i, as compared to patients with heart failure without this therapy. Modulation of EAT inflammatory and metabolic status could represent a novel mechanism behind SGLT-2i-associated cardioprotective effects in patients with heart failure.
Permanent Link: https://hdl.handle.net/11104/0355373