Mechanical regulation of mitochondrial morphodynamics in cancer cells by extracellular microenvironment

0587163 - FZÚ 2025 RIV GB eng J - Journal Article
Lunova, Mariia - Jirsa, M. - Dejneka, Alexandr - Sullivan, G.J. - Lunov, Oleg
Mechanical regulation of mitochondrial morphodynamics in cancer cells by extracellular microenvironment.
Biomaterials and Biosystems. Roč. 14, June (2024), č. článku 100093. ISSN 2666-5344
R&D Projects: GA ČR(CZ) GA22-18634S
Grant - others:AV ČR(CZ) StrategieAV21/26
Program: StrategieAV
Institutional support: RVO:68378271
Keywords : cancer * tumor metabolism * mechanotransduction * mitochondria * mitochondrial dynamics
OECD category: Biophysics
Method of publishing: Open access

Recently, it has been recognized that physical abnormalities (e.g. elevated solid stress, elevated interstitial fluid pressure, increased stiffness) are associated with tumor progression and development. Mitochondria are well-known as bioenergetic, biosynthetic, and signaling organelles crucial for sensing stress and facilitating cellular adaptation to the environment and physical stimuli. Consequently, it is logical to hypothesize that mitochondria dynamics subjected to physical cues may play a pivotal role in mediating tumorigenesis. However, how cancer cell mechanics and mitochondria functions are connected, still remain poorly understood. Here, we discuss recent studies that link mechanical stimuli exerted by the tumor cell environment and mitochondria dynamics and functions. This interplay between mechanics and mitochondria functions may shed light on how mitochondria regulate tumorigenesis.
Permanent Link: https://hdl.handle.net/11104/0354436