0587121 - FZÚ 2025 RIV US eng J - Journal Article
Elblová, Petra - Lunova, Mariia - Dejneka, Alexandr - Jirsa, M. - Lunov, Oleg
Impact of mechanical cues on key cell functions and cell-nanoparticle interactions.
Discover Nano. Roč. 19, June (2024), č. článku 106. E-ISSN 2731-9229
R&D Projects: GA ČR(CZ) GA22-18634S
Institutional support: RVO:68378271
Keywords : nanomedicine * nanoparticles * mechanotransduction * mechanical cues * extracellular matrix
OECD category: Biophysics
Method of publishing: Open access
DOI: https://doi.org/10.1186/s11671-024-04052-2

It has been recognized that mechanical forces play an important regulative role in living organisms and possess a direct impact on crucial cell functions, ranging from cell growth to maintenance of tissue homeostasis. Notably, numerous studies have elucidated the pivotal role of different mechanical cues as regulatory factors influencing various cellular processes, including cell spreading, locomotion, differentiation, and proliferation. Nevertheless, our knowledge on how localized physical forces affect the internalization and processing of nanoparticles by cells remains rather limited. Hence, our aim in this review is to provide a comprehensive and critical analysis of the existing knowledge regarding the influence of mechanical cues on the complicated dynamics of cell-nanoparticle interactions. By addressing this gap, we would like to contribute to a detailed understanding of the role that mechanical forces play in shaping the complex interplay between cells and nanoparticles.
Permanent Link: https://hdl.handle.net/11104/0354403