Structure and absolute configuration of natural fungal product beauveriolide I, isolated from Cordyceps javanica, determined by 3D electron diffraction

0585739 - FZÚ 2025 RIV GB eng J - Journal Article
Gurung, Kshitij - Šimek, Petr - Jegorov, Alexandr - Palatinus, Lukáš
Structure and absolute configuration of natural fungal product beauveriolide I, isolated from Cordyceps javanica, determined by 3D electron diffraction.
Acta Crystallographica Section C-Structural Chemistry. Roč. 80, Mar (2024), s. 56-61. ISSN 2053-2296. E-ISSN 2053-2296
R&D Projects: GA ČR(CZ) GX21-05926X; GA MŠMT LM2023051; GA TA ČR(CZ) SS01020450
Institutional support: RVO:68378271 ; RVO:60077344
Keywords : crystal structure * natural product * 3D electron diffraction * absolute structure * Alzheimer’s disease
OECD category: Condensed matter physics (including formerly solid state physics, supercond.); Biochemistry and molecular biology (BC-A)
Impact factor: 0.8, year: 2022
Method of publishing: Open access

Beauveriolides, including the main beauveriolide I {systematic name: (3R,6S,9S,13S)-9-benzyl-13-[(2S)-hexan-2-yl]-6-methyl-3-(2-methylpropyl)-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone, C27H41N3O5}, are a series of cyclodepsipeptides that have shown promising results in the treatment of Alzheimer’s disease and in the prevention of foam cell formation in atherosclerosis. Their crystal structure studies have been difficult due to their tiny crystal size and fibre-like morphology, until now. Recent developments in 3D electron diffraction methodology have made it possible to accurately study the crystal structures of submicron crystals by overcoming the problems of beam sensitivity and dynamical scattering. In this study, the absolute structure of beauveriolide I was determined by 3D electron diffraction.
Permanent Link: https://hdl.handle.net/11104/0353439