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Radial flow enhances QCM biosensor sensitivity
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SYSNO ASEP 0585171 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Radial flow enhances QCM biosensor sensitivity Author(s) Lynn, Nicholas Scott (FZU-D) ORCID
Forinová, Michala (FZU-D) ORCID
Spasovová, Monika (FZU-D) ORCID
Vaisocherová-Lísalová, Hana (FZU-D) ORCID
Yudin, Petr (FZU-D) ORCIDNumber of authors 5 Article number 134949 Source Title Sensors and Actuators B - Chemical. - : Elsevier
Roč. 401, Feb (2024)Number of pages 8 s. Language eng - English Country NL - Netherlands Keywords biosensor ; quartz crystal microbalance ; radial flow ; microfluidics ; diffusion limitations ; detection of Escherichia coli Subject RIV BO - Biophysics OECD category Biophysics R&D Projects GA22-20012S GA ČR - Czech Science Foundation (CSF) Institutional support FZU-D - RVO:68378271 UT WOS 001146836700001 EID SCOPUS 85177204100 DOI 10.1016/j.snb.2023.134949 Annotation QCM biosensors are widely used for the detection of a variety of pathogenic microorganisms, and there remains a need for further increases in sensitivity. The majority of QCM biosensors are operated under diffusion-limited conditions that, when used with a standard flow cell, lead to the majority of analyte being captured onto re- gions of the crystal surface that have limited to no mass sensitivity. Here we show that simple changes to a flow cell architecture (reduction of flow cell height) can provide increases in sensing signal. Furthermore, we show that the use of radial flow will lead to analyte capture directly in the sensitive region of a crystal, thus providing dramatic increases in the biosensor’s sensitivity. We examine this problem from both a theoretical and numerical perspective and present a new method by which to consider how changes to a sensing assay will affect sensor sensitivity. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2025
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