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Prebiotic Synthesis of 3',5'-Cyclic Adenosine and Guanosine Monophosphates through Carbodiimide-Assisted Cyclization
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SYSNO ASEP 0583702 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Prebiotic Synthesis of 3',5'-Cyclic Adenosine and Guanosine Monophosphates through Carbodiimide-Assisted Cyclization Author(s) Coulon, Rémi (BFU-R)
Papoušková, B. (CZ)
Mohammadi, E. (CZ)
Otyepka, M. (CZ)
Wunnava, S. (DE)
Šponer, Jiří (BFU-R) RID, ORCID
Šponer, Judit E. (BFU-R) RID, ORCIDNumber of authors 7 Source Title Chembiochem. - : Wiley - ISSN 1439-4227
Roč. 24, č. 24 (2023)Number of pages 4 s. Language eng - English Country US - United States Keywords formamide ; phosphorylation ; nucleosides ; 1st ; cyclization ; formamide ; nucleotides ; prebiotic chemistry ; rna Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology R&D Projects GA22-25057S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support BFU-R - RVO:68081707 UT WOS 001084821700001 EID SCOPUS 85174297224 DOI 10.1002/cbic.202300510 Annotation 3',5'-Cyclic nucleotides play a fundamental role in modern biochemical processes and have been suggested to have played a central role at the origin of terrestrial life. In this work, we suggest that a formamide-based systems chemistry might account for their availability on the early Earth. In particular, we demonstrate that in a liquid formamide environment at elevated temperatures 3',5'-cyclic nucleotides are obtained in good yield and selectivity upon intramolecular cyclization of 5'-phosphorylated nucleosides in the presence of carbodiimides. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2024 Electronic address https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202300510
Number of the records: 1