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Development of ventricular trabeculae affects electrical conduction in the early endothermic heart
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SYSNO ASEP 0583231 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Development of ventricular trabeculae affects electrical conduction in the early endothermic heart Author(s) Olejníčková, Veronika (FGU-C) RID, ORCID, SAI
Hamor, P. U. (CZ)
Janáček, Jiří (FGU-C) RID, ORCID
Bartoš, M. (CZ)
Zábrodská, E. (CZ)
Šaňková, B. (CZ)
Kvasilová, A. (CZ)
Kolesová, Hana (FGU-C) RID, ORCID, SAI
Sedmera, David (FGU-C) RID, ORCID, SAISource Title Developmental Dynamics. - : Wiley - ISSN 1058-8388
Roč. 253, č. 1 (2024), s. 78-90Number of pages 13 s. Language eng - English Country US - United States Keywords embryonic chick heart ; neuregulin/ErbB ; ventricular trabeculae OECD category Anatomy and morphology (plant science to be 1.6) R&D Projects LX22NPO5104 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) NU21J-02-00039 GA MZd - Ministry of Health (MZ) Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 000891509100001 EID SCOPUS 85142921151 DOI https://doi.org/10.1002/dvdy.552 Annotation Background:The ventricular trabeculae play a role, among others, in the impulse spreading in ectothermic hearts. Despite the morphological similarity with the early developing hearts of endotherms, this trabecular function in mammalian and avian embryos was poorly addressed.Results:We simulated impulse propagation inside the looping ventricle and revealed delayed apical activation in the heart with inhibited trabecular growth. This finding was corroborated by direct imaging of the endocardial surface showing early activation within the trabeculae implying preferential spreading of depolarization along with them. Targeting two crucial pathways of trabecular formation (Neuregulin/ErbB and Nkx2.5), we showed that trabecular development is also essential for proper conduction patterning. Persistence of the slow isotropic conduction likely contributed to the pumping failure in the trabeculae-deficient hearts.Conclusions:Our results showed the essential role of trabeculae in intraventricular impulse spreading and conduction patterning in the early endothermic heart. Lack of trabeculae leads to the failure of conduction parameters differentiation resulting in primitive ventricular activation with consequent impact on the cardiac pumping function. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2025 Electronic address https://doi.org/10.1002/dvdy.552
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