Development of ventricular trabeculae affects electrical conduction in the early endothermic heart

0583231 - FGÚ 2025 RIV US eng J - Journal Article
Olejníčková, Veronika - Hamor, P. U. - Janáček, Jiří - Bartoš, M. - Zábrodská, E. - Šaňková, B. - Kvasilová, A. - Kolesová, Hana - Sedmera, David
Development of ventricular trabeculae affects electrical conduction in the early endothermic heart.
Developmental Dynamics. Roč. 253, č. 1 (2024), s. 78-90. ISSN 1058-8388. E-ISSN 1097-0177
R&D Projects: GA MŠMT(CZ) LX22NPO5104; GA MZd(CZ) NU21J-02-00039
Institutional support: RVO:67985823
Keywords : embryonic chick heart * neuregulin/ErbB * ventricular trabeculae
OECD category: Anatomy and morphology (plant science to be 1.6)
Impact factor: 2.5, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/dvdy.552

Background:The ventricular trabeculae play a role, among others, in the impulse spreading in ectothermic hearts. Despite the morphological similarity with the early developing hearts of endotherms, this trabecular function in mammalian and avian embryos was poorly addressed.Results:We simulated impulse propagation inside the looping ventricle and revealed delayed apical activation in the heart with inhibited trabecular growth. This finding was corroborated by direct imaging of the endocardial surface showing early activation within the trabeculae implying preferential spreading of depolarization along with them. Targeting two crucial pathways of trabecular formation (Neuregulin/ErbB and Nkx2.5), we showed that trabecular development is also essential for proper conduction patterning. Persistence of the slow isotropic conduction likely contributed to the pumping failure in the trabeculae-deficient hearts.Conclusions:Our results showed the essential role of trabeculae in intraventricular impulse spreading and conduction patterning in the early endothermic heart. Lack of trabeculae leads to the failure of conduction parameters differentiation resulting in primitive ventricular activation with consequent impact on the cardiac pumping function.
Permanent Link: https://hdl.handle.net/11104/0351233