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A new role of sigma factors in regulation of bacterial transcription
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SYSNO ASEP 0581866 Document Type A - Abstract R&D Document Type O - Ostatní Title A new role of sigma factors in regulation of bacterial transcription Author(s) Pospíšil, Jiří (MBU-M) ORCID, RID
Schwarz, Marek (MBU-M) ORCID, RID
Ziková, Alice (MBU-M)
Vítovská, Dragana (MBU-M) ORCID
Hradilová, Miluše (UMG-J)
Kolář, Michal (UMG-J) RID, ORCID
Křenková, Alena (UOCHB-X) ORCID, RID
Hubálek, Martin (UOCHB-X) RID, ORCID
Krásný, Libor (MBU-M) RID, ORCID
Vohradský, Jiří (MBU-M) RID, ORCIDSource Title Czech Chem. Soc. Symp. Series
Roč. 21, č. 5 (2023), s. 210-210Number of pages 1 s. Publication form Print - P Action Annual meeting of the National Institute of Virology and Bacteriology (NIVB) /2./ Event date 02.10.2023 - 05.10.2023 VEvent location Kutná Hora Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords gene expression ; sigma factors ; RNA polymerase OECD category Microbiology R&D Projects LX22NPO5103 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support MBU-M - RVO:61388971 ; UMG-J - RVO:68378050 ; UOCHB-X - RVO:61388963 Annotation Bacterial gene expression is controlled by sigma (σ) factors, that bind to RNA polymerase (RNAP), recognize specific promoter sequences in DNA, and mediate transcription initiation. Bacteria always contain one primary or so called “housekeeping” σ factor. In the gram-positive antibiotic producing bacterium, Streptomyces coelicolor, 65 genes encoding different σ factors are found. HrdB is the main sigma factor in S. coelicolor and is responsible for expression of essential genes. On the other hand, genes that are required in different stresses or environmental conditions are regulated by alternative σ factors. Alternative σ factors are typically about half the size (~30 kDa) of HrdB and lack some of its domains. These factors recognize promoter consensus sequences different from HrdB. They are responsible for transcription of gene subsets with specific functions1,2 Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2024
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