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Application of microfluidic reactor for phase transfer catalysed N-alkylation

SYSNO ASEP	0580646
Document Type	A - Abstract
R&D Document Type	The record was not marked in the RIV
R&D Document Type	Není vybrán druh dokumentu
Title	Application of microfluidic reactor for phase transfer catalysed N-alkylation
Author(s)	Jaklová, Natalie (UCHP-M) Klusoň, Petr (UCHP-M)_{RID, ORCID, SAI} Stavárek, Petr (UCHP-M)_{RID, ORCID, SAI} Vychodilová, Hana (UCHP-M)_{RID, SAI}
Action	European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology /14./
Event date	17.09.2023 - 21.09.2023
VEvent location	Berlin
Country	DE - Germany
Event type	EUR
Language	eng - English
Keywords	microfluidic reactor ; N-alkylation ; phase transfer catalysis
OECD category	Chemical process engineering
Institutional support	UCHP-M - RVO:67985858
Annotation	The main topic of the contribution is the transfer of the batch N-alkylation reaction to the continuous regime. This involves the alkylation of the methyl ester of 10αmethoxydihydrolysergic acid (LUME) to form the methyl ester of 1-methyl-10αmethoxydihydrolysergic acid (MeLUME). The chosen methylation reaction is part of the production of Nicergoline, a drug used to promote cognitive function in patients suffering from senile and presenile syndrome of vascular or degenerative origin, or to promote peripheral blood flow.
Workplace	Institute of Chemical Process Fundamentals
Contact	Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227
Year of Publishing	2024

Number of the records: 1