Number of the records: 1
Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract
- 1.
SYSNO ASEP 0580525 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract Author(s) Oral, C.M.M. (CZ)
Ussia, M. (CZ)
Urso, M. (CZ)
Salát, Jiří (BC-A) RID, ORCID
Novobilský, A. (CZ)
Štefánik, M. (CZ)
Růžek, Daniel (BC-A) RID, ORCID
Pumera, M. (CZ)Number of authors 8 Article number 2202682 Source Title Advanced Healthcare Materials. - : Wiley - ISSN 2192-2640
Roč. 12, MAR (2022)Number of pages 9 s. Publication form Online - E Language eng - English Country US - United States Keywords nanoparticles ; computed tomography ; gastrointestinal tract ; magnetic actuation ; medical imaging ; nanomotors ; nanoswimmers ; tracking Subject RIV EE - Microbiology, Virology OECD category Microbiology Method of publishing Limited access Institutional support BC-A - RVO:60077344 UT WOS 000903078100001 EID SCOPUS 85145028340 DOI 10.1002/adhm.202202682 Annotation Magnetic nanorobots offer wireless navigation capability in hard-to-reach areas of the human body for targeted therapy and diagnosis. Though in vivo imaging is required for guidance of the magnetic nanorobots toward the target areas, most of the imaging techniques are inadequate to reveal the potential locomotion routes. This work proposes the use of radiopaque magnetic nanorobots along with microcomputed tomography (microCT) for localized in vivo imaging applications. The nanorobots consist of a contrast agent, barium sulfate (BaSO4), magnetized by the decoration of magnetite (Fe3O4) particles. The magnetic features lead to actuation under rotating magnetic fields and enable precise navigation in a microfluidic channel used to simulate confined spaces of the body. In this channel, the intrinsic radiopacity of the nanorobots also provides the possibility to reveal the internal structures by X-ray contrast. Furthermore, in vitro analysis indicates nontoxicity of the nanorobots. In vivo experiments demonstrate localization of the nanorobots in a specific part of the gastrointestinal (GI) tract upon the influence of the magnetic field, indicating the efficient control even in the presence of natural peristaltic movements. The nanorobots reported here highlight that smart nanorobotic contrast agents can improve the current imaging-based diagnosis techniques by providing untethered controllability in vivo. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2024 Electronic address https://onlinelibrary.wiley.com/doi/10.1002/adhm.202202682
Number of the records: 1