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Omne vivum ex ovo: the oocyte reprogramming and remodeling activities
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SYSNO ASEP 0580371 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Omne vivum ex ovo: the oocyte reprogramming and remodeling activities Author(s) Fulka, Helena (UEM-P)
Loi, P. (IT)
Czernik, M. (IT)
Surani, A. (GB)
Fulka Jr, J. (CZ)Source Title Reproduction. - : BioScientifica - ISSN 1470-1626
Roč. 165, č. 3 (2023), R75-R89Number of pages 15 s. Language eng - English Country GB - United Kingdom Keywords topologically associating domains ; zygotic genome activation ; full-term development ; nuclear transfer OECD category Reproductive biology (medical aspects to be 3) R&D Projects GF21-42225L GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 000941438400001 EID SCOPUS 85146193684 DOI 10.1530/REP-22-0124 Annotation The mammalian oocyte is a unique cell, and comprehending its physiology and biology is essential for understanding fertilization, totipotency and early events of embryogenesis. Consequently, research in these areas influences the outcomes of various technologies, for example, the production and conservation of laboratory and large animals with rare and valuable genotypes, the rescue of the species near extinction, as well as success in human assisted reproduction. Nevertheless, even the most advanced and sophisticated reproductive technologies of today do not always guarantee a favorable outcome. Elucidating the interactions of oocyte components with its natural partner cell - the sperm or an 'unnatural' somatic nucleus, when the somatic cell nucleus transfer is used is essential for understanding how totipotency is established and thus defining the requirements for normal development. One of the crucial aspects is the stoichiometry of different reprogramming and remodeling factors present in the oocyte and their balance. Here, we discuss how these factors, in combination, may lead to the formation of a new organism. We focus on the laboratory mouse and its genetic models, as this species has been instrumental in shaping our understanding of early post-fertilization events. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2024 Electronic address https://rep.bioscientifica.com/view/journals/rep/165/3/REP-22-0124.xml
Number of the records: 1