Poly(glycerol monomethacrylate)-encapsulated upconverting nanoparticles prepared by miniemulsion polymerization: morphology, chemical stability, antifouling properties and toxicity evaluation

Vasylyshyn, Taras; Patsula, Vitalii; Filipová, Marcela; Konefal, Rafal; Horák, Daniel

doi:https://dx.doi.org/10.1039/D3NA00793F

Number of the records: 1

Poly(glycerol monomethacrylate)-encapsulated upconverting nanoparticles prepared by miniemulsion polymerization: morphology, chemical stability, antifouling properties and toxicity evaluation

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SYSNO ASEP	0579125
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Poly(glycerol monomethacrylate)-encapsulated upconverting nanoparticles prepared by miniemulsion polymerization: morphology, chemical stability, antifouling properties and toxicity evaluation
Author(s)	Vasylyshyn, Taras (UMCH-V)_RID Patsula, Vitalii (UMCH-V)_{RID, ORCID} Filipová, Marcela (UMCH-V)_{RID, ORCID} Konefal, Rafal (UMCH-V)_{RID, ORCID} Horák, Daniel (UMCH-V)_{RID, ORCID}
Source Title	Nanoscale Advances. - : Royal Society of Chemistry - ISSN 2516-0230 Roč. 5, č. 24 (2023), s. 6979-6989
Number of pages	11 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	luminescence ; upconversion ; nanoparticles
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
R&D Projects	GA21-04420S GA ČR - Czech Science Foundation (CSF)
	LX22NPO5102 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Open access
Institutional support	UMCH-V - RVO:61389013
UT WOS	001102478900001
EID SCOPUS	85178271635
DOI	10.1039/D3NA00793F
Annotation	In this report, upconverting NaYF4:Yb3+,Er3+ nanoparticles (UCNPs) were synthesized by high-temperature coprecipitation of lanthanide chlorides and encapsulated in poly(glycerol monomethacrylate) (PGMMA). The UCNP surface was first treated with hydrophobic penta(propylene glycol) methacrylate phosphate (SIPO) to improve colloidal stability and enable encapsulation by reversible addition–fragmentation chain transfer miniemulsion polymerization (RAFT) of glycidyl methacrylate (GMA) in water, followed by its hydrolysis. The resulting UCNP-containing PGMMA particles (UCNP@PGMMA), hundreds of nanometers in diameter, were thoroughly characterized by transmission (TEM) and scanning electron microscopy (SEM), dynamic light scattering (DLS), infrared (FTIR) and fluorescence emission spectroscopy, and thermogravimetric analysis (TGA) in terms of particle morphology, size, polydispersity, luminescence, and composition. The morphology, typically raspberry-like, depended on the GMA/UCNP weight ratio. Coating of the UCNPs with hydrophilic PGMMA provided the UCNPs with antifouling properties while enhancing chemical stability and reducing the cytotoxicity of neat UCNPs to a non-toxic level. In addition, it will allow the binding of molecules such as photosensitizers, thus expanding the possibilities for use in various biomedical applications.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2024
Electronic address	https://pubs.rsc.org/en/content/articlelanding/2023/NA/D3NA00793F

Number of the records: 1