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Linking Social Cognition, Parvalbumin Interneurons, and Oxytocin in Alzheimer’s Disease: An Update
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SYSNO ASEP 0579055 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Linking Social Cognition, Parvalbumin Interneurons, and Oxytocin in Alzheimer’s Disease: An Update Author(s) Černotová, Daniela (FGU-C) ORCID
Hrůzová, Karolína (FGU-C) ORCID
Levčík, David (FGU-C) RID, ORCID
Svoboda, Jan (FGU-C) RID, ORCID
Stuchlík, Aleš (FGU-C) RID, ORCIDSource Title Journal of Alzheimer's Disease. - : IOS Press - ISSN 1387-2877
Roč. 96, č. 3 (2023), s. 861-875Number of pages 15 s. Language eng - English Country NL - Netherlands Keywords Alzheimer’s disease ; animal models ; dementia ; hippocampus ; oxytocin ; parvalbumin interneurons ; social cognition ; social memor OECD category Neurosciences (including psychophysiology R&D Projects GF21-16667K GA ČR - Czech Science Foundation (CSF) LX22NPO5107 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 001106662400001 EID SCOPUS 85177984097 DOI 10.3233/JAD-230333 Annotation Finding a cure for Alzheimer’s disease (AD) has been notoriously challenging for many decades. Therefore, the current focus is mainly on prevention, timely intervention, and slowing the progression in the earliest stages. A better understanding of underlying mechanisms at the beginning of the disease could aid in early diagnosis and intervention, including alleviating symptoms or slowing down the disease progression. Changes in social cognition and progressive parvalbumin (PV) interneuron dysfunction are among the earliest observable effects of AD. Various AD rodent models mimic these early alterations, but only a narrow field of study has considered their mutual relationship. In this review, we discuss current knowledge about PV interneuron dysfunction in AD and emphasize their importance in social cognition and memory. Next, we propose oxytocin (OT) as a potent modulator of PV interneurons and as a promising treatment for managing some of the early symptoms. We further discuss the supporting evidence on its beneficial effects on AD-related pathology. Clinical trials have employed the use of OT in various neuropsychiatric diseases with promising results, but little is known about its prospective impacts on AD. On the other hand, the modulatory effects of OT in specific structures and local circuits need to be clarified in future studies. This review highlights the connection between PV interneurons and social cognition impairment in the early stages of AD and considers OT as a promising therapeutic agent for addressing these early deficits. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2024 Electronic address https://content.iospress.com/articles/journal-of-alzheimers-disease/jad230333
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