0576571 - BC 2024 RIV US eng A - Abstract
Doleželová, Eva - Kunzová, Michaela - Panicucci, Brian - Zíková, Alena
Trypanosoma brucei, a master of metabolic disguise.
European Journal of Clinical Investigation. Wiley. Roč. 53, č. 1 (2023), č. článku 57ASM - 24. ISSN 0014-2972. E-ISSN 1365-2362.
[57TH ANNUAL SCIENTIFIC MEETING-7-9 June 2023, Prague, Czech Republic. 07.06.2023-09.06.2023, Praha]
EU Projects: European Commission(XE) 101044951 - MitoSignal
Institutional support: RVO:60077344
Keywords : Dysregulation * mitochondrial * Trypanosoma brucei
OECD category: Microbiology
Result website:
https://onlinelibrary.wiley.com/doi/10.1111/eci.13992

Background: In the last decade, the importance of mitochondrially derived reactive oxygen species (OS) as signals in intracellular communication has been sealed. These though-to-be harmful molecules influence cellular faith decisions and can drive cells towards proliferation, apoptosis or differentiation. The OS are mainly generated as by-products during the process of oxidative phosphorylation (OXPHOS), which is completed by FoF1-ATP synthase with the formation of ATP. In trypanosomes, unicellular parasites undergoing programmed life cycle development, the cellular differentiation is linked to increased mitochondrial metabolic activity and OS production.
Permanent Link: https://hdl.handle.net/11104/0351107