Sulfonothioated meso-Methyl BODIPY Shows Enhanced Uncaging Efficiency and Releases H2Sn

0576178 - ÚOCHB 2024 RIV US eng J - Journal Article
Wohlrábová, Lucie - Okoročenkova, J. - Palao, E. - Kužmová, Erika - Chalupský, Karel - Klán, P. - Slanina, Tomáš
Sulfonothioated meso-Methyl BODIPY Shows Enhanced Uncaging Efficiency and Releases H2Sn.
Organic Letters. Roč. 25, č. 36 (2023), s. 6705-6709. ISSN 1523-7060. E-ISSN 1523-7052
R&D Projects: GA ČR(CZ) GA22-20319S
Research Infrastructure: RECETOX RI - 90121
Institutional support: RVO:61388963
Keywords : hydrogen-sulfide * cytotoxicity * mitochondria
OECD category: Organic chemistry
Impact factor: 5.2, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.orglett.3c02511

meso-Methyl BODIPY photocages stand out for their absorption properties and easy chromophore derivatization. However, their low uncaging efficiencies often hinder applications requiring release of protected substrates in high amounts. In this study, we demonstrate that the sulfonothioated BODIPY group photocleaves a sulfonylthio group from the meso-methyl position with a 10-fold higher quantum yield than the most efficient leaving groups studied to date. Photocleavage, observed in solution and in cells, is accompanied by the spatiotemporally controlled photorelease of H2Sn. For this reason, sulfonothioated BODIPY may be applied in cell signaling, redox homeostasis, and metabolic regulation studies.
Permanent Link: https://hdl.handle.net/11104/0345764