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Characterization of newly synthesized labels for analysis of oligosaccharides and glycans by LC/FLD-MS
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SYSNO ASEP 0575804 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title Characterization of newly synthesized labels for analysis of oligosaccharides and glycans by LC/FLD-MS Author(s) Smolková, Denisa (UIACH-O)
Čmelík, Richard (UIACH-O) RID
Greguš, M. (CZ)
Veselý, H. (CZ)
Pizová, H. (CZ)
Bobáľ, P. (CZ)
Lavická, Jana (UIACH-O) ORCID, RIDNumber of authors 7 Source Title Abstrakty přednášek v sekci Mládí vpřed a plakátových sdělení 24. ročníku Školy hmotnostní spektrometrie. - Brno : Spektroskopická společnost Jana Marka Marci, 2023 / Cvačka J. ; Vrkoslav V. ; Hubálek M. ; Vlk M. - ISBN 978-80-88195-43-6
S. 50-50Number of pages 1 s. Publication form Print - P Action Škola hmotnostní spektrometrie /24./ Event date 10.09.2023 - 15.09.2023 VEvent location Milovy Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords LC/FLD-MS analysis ; oligosaccharides Subject RIV CB - Analytical Chemistry, Separation OECD category Analytical chemistry R&D Projects GA22-00236S GA ČR - Czech Science Foundation (CSF) Institutional support UIACH-O - RVO:68081715 Annotation In this work, we present the synthesis of a new fluorescent label suitable for oligosaccharides and glycan analysis by LC with fluorescence and MS detection (LC/FLD-MS). The novel hydrazide derivative of dipyrrometheneboron difluoride (BODIPY) has been synthesized from 2,4-dimethylpyrrole, methyl 4-chloro-4-oxobutanoate and boron trifluoride etherate followed by hydrazinolysis. The novel synthesized label was characterized by several analytical methods including UV/Vis and fluorescence spectroscopy, and MS. Derivatization of oligosaccharides and N-linked glycans by novel fluorescent label was performed via hydrazone formation chemistry under mild conditions followed by LC/FLD-MS analysis.
Workplace Institute of Analytical Chemistry Contact Iveta Drobníková, drobnikova@iach.cz, Tel.: 532 290 234 Year of Publishing 2024 Electronic address http://skolams2023.spektroskopie.cz/files/abstrakty_sbornik_SkolaMS2023.pdf
Number of the records: 1