Tuning polymer-blood and polymer-cytoplasm membrane interactions by manipulating the architecture of poly(2-oxazoline) triblock copolymers

Lobaz, Volodymyr; Liščáková, Veronika; Sedlák, František; Musil, Dominik; Lukáš Petrova, Svetlana; Šeděnková, Ivana; Pánek, Jiří; Kučka, Jan; Konefal, Rafal; Tihlaříková, Eva; Neděla, Vilém; Pankrác, J.; Šefc, L.; Hrubý, Martin; Šácha, Pavel; Štěpánek, Petr

doi:https://dx.doi.org/10.1016/j.colsurfb.2023.113564

Number of the records: 1

Tuning polymer-blood and polymer-cytoplasm membrane interactions by manipulating the architecture of poly(2-oxazoline) triblock copolymers

1.

SYSNO ASEP	0575786
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Tuning polymer-blood and polymer-cytoplasm membrane interactions by manipulating the architecture of poly(2-oxazoline) triblock copolymers
Tvůrce(i)	Lobaz, Volodymyr (UMCH-V)_{RID, ORCID} Liščáková, Veronika (UOCHB-X)_ORCID Sedlák, František (UOCHB-X)_{RID, ORCID} Musil, Dominik (UOCHB-X)_ORCID Lukáš Petrova, Svetlana (UMCH-V)_{ORCID, RID} Šeděnková, Ivana (UMCH-V)_RID Pánek, Jiří (UMCH-V)_{RID, ORCID} Kučka, Jan (UMCH-V)_{RID, ORCID} Konefal, Rafal (UMCH-V)_{RID, ORCID} Tihlaříková, Eva (UPT-D)_{RID, ORCID, SAI} Neděla, Vilém (UPT-D)_{RID, ORCID, SAI} Pankrác, J. (CZ) Šefc, L. (CZ) Hrubý, Martin (UMCH-V)_{RID, ORCID} Šácha, Pavel (UOCHB-X)_{RID, ORCID} Štěpánek, Petr (UMCH-V)_{RID, ORCID}
Číslo článku	113564
Zdroj.dok.	Colloids and Surfaces B-Biointerfaces. - : Elsevier - ISSN 0927-7765 Roč. 231, November (2023)
Poč.str.	9 s.
Jazyk dok.	eng - angličtina
Země vyd.	NL - Nizozemsko
Klíč. slova	amphiphilic triblock polyoxazoline ; drug delivery ; blood proteins
Obor OECD	Polymer science
Vědní obor RIV – spolupráce	Ústav makromolekulární chemie - Makromolekulární chemie Ústav organické chemie a biochemie - Biochemie Ústav přístrojové techniky - Elektronika a optoelektronika, elektrotechnika
CEP	NU22-03-00318 GA MZd - Ministerstvo zdravotnictví
	GA21-04166S GA ČR - Grantová agentura ČR
	GA22-25799S GA ČR - Grantová agentura ČR
	LX22NPO5102 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
	LM2023053 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Způsob publikování	Open access
Institucionální podpora	UMCH-V - RVO:61389013 ; UOCHB-X - RVO:61388963 ; UPT-D - RVO:68081731
UT WOS	001082347700001
EID SCOPUS	85171621348
DOI	https://doi.org/10.1016/j.colsurfb.2023.113564
Anotace	Bioactive moieties designed to bind to cell membrane receptors benefit from coupling with polymeric carriers that have enhanced affinity to the cell membrane. When bound to the cell surface, such carriers create a “2D solution” of a ligand with a significantly increased concentration near a membrane-bound receptor compared to a freely water-soluble ligand. Bifunctional polymeric carriers based on amphiphilic triblock copolymers were synthesized from 2-pent-4-ynyl oxazoline, 2-nonyl oxazoline and 2-ethyl oxazoline. Their self-assembly and interactions with plasma proteins and HEK 293 cells were studied in detail. The affinity of these triblock copolymers to HEK 293 cell membranes and organ tissues was tunable by the overall hydrophobicity of the polymer molecule, which is determined by the length of the hydrophobic and hydrophilic blocks. The circulation time and biodistribution of three representative triblock copolymers were monitored after intravenous administration to C57BL/6 albino mice. A prolonged circulation time was observed for polymers with longer hydrophobic blocks, despite their molecular weight being below the renal threshold.
Pracoviště	Ústav makromolekulární chemie
Kontakt	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Rok sběru	2024
Elektronická adresa	https://www.sciencedirect.com/science/article/pii/S0927776523004423?via%3Dihub

Number of the records: 1