Tuning polymer-blood and polymer-cytoplasm membrane interactions by manipulating the architecture of poly(2-oxazoline) triblock copolymers

Lobaz, Volodymyr; Liščáková, Veronika; Sedlák, František; Musil, Dominik; Lukáš Petrova, Svetlana; Šeděnková, Ivana; Pánek, Jiří; Kučka, Jan; Konefal, Rafal; Tihlaříková, Eva; Neděla, Vilém; Pankrác, J.; Šefc, L.; Hrubý, Martin; Šácha, Pavel; Štěpánek, Petr

doi:https://dx.doi.org/10.1016/j.colsurfb.2023.113564

Number of the records: 1

Tuning polymer-blood and polymer-cytoplasm membrane interactions by manipulating the architecture of poly(2-oxazoline) triblock copolymers

1.

SYSNO ASEP	0575786
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Tuning polymer-blood and polymer-cytoplasm membrane interactions by manipulating the architecture of poly(2-oxazoline) triblock copolymers
Author(s)	Lobaz, Volodymyr (UMCH-V)_{RID, ORCID} Liščáková, Veronika (UOCHB-X)_ORCID Sedlák, František (UOCHB-X)_{RID, ORCID} Musil, Dominik (UOCHB-X) Lukáš Petrova, Svetlana (UMCH-V)_{ORCID, RID} Šeděnková, Ivana (UMCH-V)_RID Pánek, Jiří (UMCH-V)_{RID, ORCID} Kučka, Jan (UMCH-V)_{RID, ORCID} Konefal, Rafal (UMCH-V)_{RID, ORCID} Tihlaříková, Eva (UPT-D)_{RID, ORCID, SAI} Neděla, Vilém (UPT-D)_{RID, ORCID, SAI} Pankrác, J. (CZ) Šefc, L. (CZ) Hrubý, Martin (UMCH-V)_{RID, ORCID} Šácha, Pavel (UOCHB-X)_{RID, ORCID} Štěpánek, Petr (UMCH-V)_{RID, ORCID}
Article number	113564
Source Title	Colloids and Surfaces B-Biointerfaces. - : Elsevier - ISSN 0927-7765 Roč. 231, November (2023)
Number of pages	9 s.
Language	eng - English
Country	NL - Netherlands
Keywords	amphiphilic triblock polyoxazoline ; drug delivery ; blood proteins
OECD category	Polymer science
Subject RIV - cooperation	Institute of Macromolecular Chemistry - Macromolecular Chemistry Institute of Organic Chemistry and Biochemistry - Biochemistry Institute of Scientific Instruments - Electronics ; Optoelectronics, Electrical Engineering
R&D Projects	NU22-03-00318 GA MZd - Ministry of Health (MZ)
	GA21-04166S GA ČR - Czech Science Foundation (CSF)
	GA22-25799S GA ČR - Czech Science Foundation (CSF)
	LX22NPO5102 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LM2023053 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Open access
Institutional support	UMCH-V - RVO:61389013 ; UOCHB-X - RVO:61388963 ; UPT-D - RVO:68081731
UT WOS	001082347700001
EID SCOPUS	85171621348
DOI	10.1016/j.colsurfb.2023.113564
Annotation	Bioactive moieties designed to bind to cell membrane receptors benefit from coupling with polymeric carriers that have enhanced affinity to the cell membrane. When bound to the cell surface, such carriers create a “2D solution” of a ligand with a significantly increased concentration near a membrane-bound receptor compared to a freely water-soluble ligand. Bifunctional polymeric carriers based on amphiphilic triblock copolymers were synthesized from 2-pent-4-ynyl oxazoline, 2-nonyl oxazoline and 2-ethyl oxazoline. Their self-assembly and interactions with plasma proteins and HEK 293 cells were studied in detail. The affinity of these triblock copolymers to HEK 293 cell membranes and organ tissues was tunable by the overall hydrophobicity of the polymer molecule, which is determined by the length of the hydrophobic and hydrophilic blocks. The circulation time and biodistribution of three representative triblock copolymers were monitored after intravenous administration to C57BL/6 albino mice. A prolonged circulation time was observed for polymers with longer hydrophobic blocks, despite their molecular weight being below the renal threshold.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2024
Electronic address	https://www.sciencedirect.com/science/article/pii/S0927776523004423?via%3Dihub

Number of the records: 1