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Graphene Oxide Sheets Decorated with Octahedral Molybdenum Cluster Complexes for Enhanced Photoinactivation of Staphylococcus aureus

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    SYSNO ASEP0575563
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleGraphene Oxide Sheets Decorated with Octahedral Molybdenum Cluster Complexes for Enhanced Photoinactivation of Staphylococcus aureus
    Author(s) Guégan, P. (FR)
    Cheng, X. (JP)
    Huang, X. (JP)
    Němečková, Zuzana (UACH-T) SAI, RID, ORCID
    Kubáňová, M. (CZ)
    Zelenka, J. (CZ)
    Ruml, T. (CZ)
    Grasset, F. (FR)
    Sugahara, Y. (JP)
    Lang, Kamil (UACH-T) SAI, RID, ORCID
    Kirakci, Kaplan (UACH-T) SAI, RID, ORCID
    Number of authors11
    Source TitleInorganic Chemistry. - : American Chemical Society - ISSN 0020-1669
    Roč. 62, č. 35 (2023), s. 14243-14251
    Number of pages9 s.
    Languageeng - English
    CountryUS - United States
    KeywordsBacteria ; Cluster chemistry ; Colloids ; Nanocomposites ; Oxides
    Subject RIVCA - Inorganic Chemistry
    OECD categoryInorganic and nuclear chemistry
    R&D ProjectsGC21-16084J GA ČR - Czech Science Foundation (CSF)
    LM2018124 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    Method of publishingOpen access
    Institutional supportUACH-T - RVO:61388980
    UT WOS001063509700001
    EID SCOPUS85169713402
    DOI10.1021/acs.inorgchem.3c01502
    AnnotationThe emergence of multidrug-resistant microbial pathogens poses a significant threat, severely limiting the options for effective antibiotic therapy. This challenge can be overcome through the photoinactivation of pathogenic bacteria using materials generating reactive oxygen species upon exposure to visible light. These species target vital components of living cells, significantly reducing the likelihood of resistance development by the targeted pathogens. In our research, we have developed a nanocomposite material consisting of an aqueous colloidal suspension of graphene oxide sheets adorned with nanoaggregates of octahedral molybdenum cluster complexes. The negative charge of the graphene oxide and the positive charge of the nanoaggregates promoted their electrostatic interaction in aqueous medium and close cohesion between the colloids. Upon illumination with blue light, the colloidal system exerted a potent antibacterial effect against planktonic cultures of Staphylococcus aureus largely surpassing the individual contributions of the components. The underlying mechanism behind this phenomenon lies in the photoinduced electron transfer from the nanoaggregates of the cluster complexes to the graphene oxide sheets, which triggers the generation of reactive oxygen species. Thus, leveraging the unique properties of graphene oxide and light-harvesting octahedral molybdenum cluster complexes can open more effective and resilient antibacterial strategies.
    WorkplaceInstitute of Inorganic Chemistry
    ContactJana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931
    Year of Publishing2024
    Electronic addresshttps://hdl.handle.net/11104/0345325
Number of the records: 1  

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