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Graphene Oxide Sheets Decorated with Octahedral Molybdenum Cluster Complexes for Enhanced Photoinactivation of Staphylococcus aureus
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SYSNO ASEP 0575563 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Graphene Oxide Sheets Decorated with Octahedral Molybdenum Cluster Complexes for Enhanced Photoinactivation of Staphylococcus aureus Author(s) Guégan, P. (FR)
Cheng, X. (JP)
Huang, X. (JP)
Němečková, Zuzana (UACH-T) SAI, RID, ORCID
Kubáňová, M. (CZ)
Zelenka, J. (CZ)
Ruml, T. (CZ)
Grasset, F. (FR)
Sugahara, Y. (JP)
Lang, Kamil (UACH-T) SAI, RID, ORCID
Kirakci, Kaplan (UACH-T) SAI, RID, ORCIDNumber of authors 11 Source Title Inorganic Chemistry. - : American Chemical Society - ISSN 0020-1669
Roč. 62, č. 35 (2023), s. 14243-14251Number of pages 9 s. Language eng - English Country US - United States Keywords Bacteria ; Cluster chemistry ; Colloids ; Nanocomposites ; Oxides Subject RIV CA - Inorganic Chemistry OECD category Inorganic and nuclear chemistry R&D Projects GC21-16084J GA ČR - Czech Science Foundation (CSF) LM2018124 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UACH-T - RVO:61388980 UT WOS 001063509700001 EID SCOPUS 85169713402 DOI 10.1021/acs.inorgchem.3c01502 Annotation The emergence of multidrug-resistant microbial pathogens poses a significant threat, severely limiting the options for effective antibiotic therapy. This challenge can be overcome through the photoinactivation of pathogenic bacteria using materials generating reactive oxygen species upon exposure to visible light. These species target vital components of living cells, significantly reducing the likelihood of resistance development by the targeted pathogens. In our research, we have developed a nanocomposite material consisting of an aqueous colloidal suspension of graphene oxide sheets adorned with nanoaggregates of octahedral molybdenum cluster complexes. The negative charge of the graphene oxide and the positive charge of the nanoaggregates promoted their electrostatic interaction in aqueous medium and close cohesion between the colloids. Upon illumination with blue light, the colloidal system exerted a potent antibacterial effect against planktonic cultures of Staphylococcus aureus largely surpassing the individual contributions of the components. The underlying mechanism behind this phenomenon lies in the photoinduced electron transfer from the nanoaggregates of the cluster complexes to the graphene oxide sheets, which triggers the generation of reactive oxygen species. Thus, leveraging the unique properties of graphene oxide and light-harvesting octahedral molybdenum cluster complexes can open more effective and resilient antibacterial strategies. Workplace Institute of Inorganic Chemistry Contact Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931 Year of Publishing 2024 Electronic address https://hdl.handle.net/11104/0345325
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