Synthesis and Biological Evaluation of α-Tocopherol Derivatives as Potential Anticancer Agents

0575549 - ÚEB 2024 RIV CH eng J - Journal Article
Baj, A. - Rárová, L. - Ratkiewicz, M. - Strnad, Miroslav - Witkowski, Z.
Synthesis and Biological Evaluation of α-Tocopherol Derivatives as Potential Anticancer Agents.
Processes. Roč. 11, č. 6 (2023), č. článku 1860. E-ISSN 2227-9717
Institutional support: RVO:61389030
Keywords : apoptosis * cancer * mitocans * vitamin E derivatives * α-tocopheryl succinate (α-TS) * α-tocopheryloxyacetic acid (α-TEA)
OECD category: Chemical engineering (plants, products)
Impact factor: 3.5, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/pr11061860

α-Tocopheryl succinate (α-TS) and α-tocopheryloxyacetic acid (α-TEA) are potent inducers of apoptosis in cancer cells and efficient suppressors of tumors in experimental model cancer cell lines. They exhibit selective cytotoxicity against tumor cells and very limited or no toxicity toward nonmalignant cells. In the present work, a series of new α-tocopherol derivatives were synthesized as analogs of α-TS and α-TEA. The cytotoxic activity of obtained compounds was tested using three human cancer cell lines, including chronic lymphoblastic leukemia (CEM), breast adenocarcinoma (MCF7), cervical adenocarcinoma (HeLa), and normal human fibroblasts (BJ). The introduction of an alkyl substituent into the ether-linked acetic acid moiety in α-TEA increased anticancer activity. α-Tocopheryloxy-2-methylpropanoic acid with two additional geminal methyl groups was more active against CEM cells compared to α-TEA and non-toxic to normal cells. In order to acquire a deeper understanding of the biological activity of synthesized compounds, a molecular docking study was also conducted. Our research confirmed that vitamin E derivatives are interesting and valuable compounds in terms of their potential therapeutic use as anticancer agents.
Permanent Link: https://hdl.handle.net/11104/0345310