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Using surface plasmon resonance, capillary electrophoresis and diffusion-ordered NMR spectroscopy to study drug release kinetics
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SYSNO ASEP 0575184 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Using surface plasmon resonance, capillary electrophoresis and diffusion-ordered NMR spectroscopy to study drug release kinetics Author(s) Libánská, Alena (UMCH-V) RID, ORCID
Špringer, Tomáš (URE-Y)
Peštová, Lucie (URE-Y)
Kotalík, Kevin (UMCH-V)
Konefal, Rafal (UMCH-V) RID, ORCID
Šimonová, A. (CZ)
Křížek, T. (CZ)
Homola, Jiří (URE-Y) RID
Randárová, Eva (UMCH-V) RID, ORCID
Etrych, Tomáš (UMCH-V) RID, ORCIDArticle number 180 Source Title Communications Chemistry. - : Nature Publishing Group - ISSN 2399-3669
Roč. 6, č. 1 (2023)Number of pages 12 s. Language eng - English Country US - United States Keywords polymer conjugate ; drug release ; HPMA Subject RIV CD - Macromolecular Chemistry OECD category Polymer science Subject RIV - cooperation Institute of Radio Engineering and Electronics - Optics, Masers, Lasers R&D Projects NU20-08-00255 GA MZd - Ministry of Health (MZ) GJ19-00956Y GA ČR - Czech Science Foundation (CSF) LX22NPO5102 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UMCH-V - RVO:61389013 ; URE-Y - RVO:67985882 UT WOS 001058412000001 EID SCOPUS 85169162242 DOI https://doi.org/10.1038/s42004-023-00992-5 Annotation Nanomedicines, including polymer nanocarriers with controlled drug release, are considered next-generation therapeutics with advanced therapeutic properties and reduced side effects. To develop safe and efficient nanomedicines, it is crucial to precisely determine the drug release kinetics. Herein, we present application of analytical methods, i.e., surface plasmon resonance biosensor technology (SPR), capillary electrophoresis, and 1H diffusion-ordered nuclear magnetic resonance spectroscopy, which were innovatively applied for drug release determination. The methods were optimised to quantify the pH-triggered release of three structurally different drugs from a polymer carrier. The suitability of these methods for drug release characterisation was evaluated and compared using several parameters including applicability for diverse samples, the biological relevance of the experimental setup, method complexity, and the analysis outcome. The SPR method was the most universal method for the evaluation of diverse drug molecule release allowing continuous observation in the flow-through setting and requiring a small amount of sample. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2024 Electronic address https://www.nature.com/articles/s42004-023-00992-5
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