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Hypertension after the Menopause: What Can We Learn from Experimental Studies?
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SYSNO ASEP 0574955 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Hypertension after the Menopause: What Can We Learn from Experimental Studies? Author(s) Piťha, J. (CZ)
Vaněčková, Ivana (FGU-C) RID, ORCID
Zicha, Josef (FGU-C) RID, ORCID, SAISource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 72, Suppl.2 (2023), s. 91-112Number of pages 22 s. Language eng - English Country CZ - Czech Republic Keywords hypertension ; sex differences ; menopause ; ovariectomy ; timing of treatment ; experimental models OECD category Cardiac and Cardiovascular systems R&D Projects LX22NPO5104 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 001049127500002 EID SCOPUS 85167679666 DOI 10.33549/physiolres.935151 Annotation Hypertension is the most prevalent cardiovascular disease of the adult population and is closely associated with serious cardiovascular events. The burden of hypertension with respect to vascular and other organ damage is greater in women. These sex differences are not fully understood. The unique feature in women is their transition to menopause accompanied by profound hormonal changes that affect the vasculature that are also associated with changes of blood pressure. Results from studies of hormone replacement therapy and its effects on the cardiovascular system are controversial, and the timing of treatment after menopause seems to be important. Therefore, revealing potential sex-and sex hormone-dependent pathophysiological mechanisms of hypertension in experimental studies could provide valuable information for better treatment of hypertension and vascular impairment, especially in postmenopausal women. The experimental rat models subjected to ovariectomy mimicking menopause could be useful tools for studying the mechanisms of blood pressure regulation after menopause and during subsequent therapy. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2024 Electronic address https://www.biomed.cas.cz/physiolres/pdf/2023/72_S91.pdf
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