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The role of GABAB receptors in the subcortical pathways of the mammalian auditory system
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SYSNO ASEP 0574202 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The role of GABAB receptors in the subcortical pathways of the mammalian auditory system Author(s) Tureček, Rostislav (UEM-P) RID, ORCID
Melichar, Adolf (UEM-P)
Králíková, Michaela (UEM-P) RID
Hrušková, Bohdana (UEM-P)Article number 1195038 Source Title Frontiers in Endocrinology. - : Frontiers Media - ISSN 1664-2392
Roč. 14, aug. (2023)Number of pages 14 s. Language eng - English Country CH - Switzerland Keywords GABAB receptor ; auditory ; Synaptic Transmission ; Neuronal excitability ; Hearing Loss ; Tinnitus OECD category Neurosciences (including psychophysiology R&D Projects LX22NPO5107 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA21-17085S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 001082212100001 EID SCOPUS 85168796550 DOI 10.3389/fendo.2023.1195038 Annotation GABAB receptors are G-protein coupled receptors for the inhibitory neurotransmitter GABA. Functional GABAB receptors are formed as heteromers of GABAB1 and GABAB2 subunits, which further associate with various regulatory and signaling proteins to provide receptor complexes with distinct pharmacological and physiological properties. GABAB receptors are widely distributed in nervous tissue, where they are involved in a number of processes and in turn are subject to a number of regulatory mechanisms. In this review, we summarize current knowledge of the cellular distribution and function of the receptors in the inner ear and auditory pathway of the mammalian brainstem and midbrain. The findings suggest that in these regions, GABAB receptors are involved in processes essential for proper auditory function, such as cochlear amplifier modulation, regulation of spontaneous activity, binaural and temporal information processing, and predictive coding. Since impaired GABAergic inhibition has been found to be associated with various forms of hearing loss, GABAB dysfunction could also play a role in some pathologies of the auditory system. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2024 Electronic address https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1195038/full
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