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Bipyridine Ruthenium(II) Complexes with Halogen-Substituted Salicylates: Synthesis, Crystal Structure, and Biological Activity

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    0573734 - ÚACH 2024 RIV CH eng J - Journal Article
    Schoeller, M. - Piroš, M. - Litecká, Miroslava - Koňariková, K. - Jozefíková, F. - Šagátová, A. - Zahradníková, E. - Valentová, J. - Moncol, J.
    Bipyridine Ruthenium(II) Complexes with Halogen-Substituted Salicylates: Synthesis, Crystal Structure, and Biological Activity.
    Molecules. Roč. 28, č. 12 (2023), č. článku 4609. E-ISSN 1420-3049
    Institutional support: RVO:61388980
    Keywords : anticancer drugs * antiproliferative activity * BSA * crystal structure * DNA * NSAID * Ruthenium(II) * salicylate
    OECD category: Inorganic and nuclear chemistry
    Impact factor: 4.6, year: 2022
    Method of publishing: Open access

    Ruthenium complexes currently represent a perspective subject of investigation in terms of potential anticancer therapeutics. Eight novel octahedral ruthenium(II) complexes are the subject of this article. Complexes contain 2,2′-bipyridine molecules and salicylates as ligands, differing in position and type of halogen substituent. The structure of the complexes was determined via X-ray structural analysis and NMR spectroscopy. All complexes were characterized by spectral methods—FTIR, UV–Vis, ESI-MS. Complexes show sufficient stability in solutions. Therefore, their biological properties were studied. Binding ability to BSA, interaction with DNA, as well as in vitro antiproliferative effects against MCF-7 and U-118MG cell lines were investigated. Several complexes showed anticancer effects against these cell lines.
    Permanent Link: https://hdl.handle.net/11104/0344119


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