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Incidental temporal binding in rats: A novel behavioral task
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SYSNO ASEP 0573318 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Incidental temporal binding in rats: A novel behavioral task Author(s) Radostová, Dominika (FGU-C) ORCID, RID, SAI
Kunčická, Daniela (FGU-C) ORCID, RID
Krajčovič, Branislav (FGU-C) ORCID, RID
Hejtmánek, Lukáš (FGU-C) RID, ORCID
Petrásek, Tomáš (FGU-C) RID, ORCID, SAI
Svoboda, Jan (FGU-C) RID, ORCID
Stuchlík, Aleš (FGU-C) RID, ORCID
Brožka, Hana (FGU-C) ORCID, SAI, RIDArticle number e0274437 Source Title PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 18, č. 6 (2023)Number of pages 15 s. Language eng - English Country US - United States Keywords OTTER ; memory ; animal behavior ; learning OECD category Neurosciences (including psychophysiology R&D Projects GA20-00939S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 001020093300016 EID SCOPUS 85162814316 DOI https://doi.org/10.1371/journal.pone.0274437 Annotation We designed a behavioral task called One-Trial Trace Escape Reaction (OTTER), in which rats incidentally associate two temporally discontinuous stimuli: a neutral acoustic cue (CS) with an aversive stimulus (US) which occurs two seconds later (CS-2s-US sequence). Rats are first habituated to two similar environmental contexts (A and B), each consisting of an interconnected dark and light chamber. Next, rats experience the CS-2s-US sequence in the dark chamber of one of the contexts (either A or B), the US is terminated immediately after a rat escapes into the light chamber. The CS-2s-US sequence is presented only once to ensure the incidental acquisition of the association. The recall is tested 24 h later when rats are presented with only the CS in the alternate context (B or A), and their behavioral response is observed. Our results show that 59% of the rats responded to the CS by escaping to the light chamber, although they experienced only one CS-2s-US pairing. The OTTER task offers a flexible high throughput tool to study memory acquired incidentally after a single experience. Incidental one-trial acquisition of association between temporally discontinuous events may be one of the essential components of episodic memory formation. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2024 Electronic address https://doi.org/10.1371/journal.pone.0274437
Number of the records: 1