Number of the records: 1
Inappropriate activation of the renin-angiotensin system improves cardiac tolerance to ischemia/reperfusion injury in rats with late angiotensin II-dependent hypertension
- 1.
SYSNO ASEP 0573301 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Inappropriate activation of the renin-angiotensin system improves cardiac tolerance to ischemia/reperfusion injury in rats with late angiotensin II-dependent hypertension Author(s) Husková, Z. (CZ)
Kikerlová, S. (CZ)
Miklovič, M. (CZ)
Kala, P. (CZ)
Papoušek, František (FGU-C)
Neckář, Jan (FGU-C) RID, ORCIDArticle number 1151308 Source Title Frontiers in Physiology. - : Frontiers Research Foundation - ISSN 1664-042X
Roč. 14, 14 June (2023)Number of pages 13 s. Language eng - English Country CH - Switzerland Keywords renin-angiotensin system ; ischemia/reperfusion injury ; ANG II-dependent hypertension ; AT1 receptor antagonist ; P-V analysis OECD category Cardiac and Cardiovascular systems R&D Projects LX22NPO5104 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) NV18-02-00014 GA MZd - Ministry of Health (MZ) Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 001021310700001 EID SCOPUS 85163754703 DOI https://doi.org/10.3389/fphys.2023.1151308 Annotation The aim of the study was to clarify the role of the interplay between hypertension and the renin-angiotensin system (RAS) in the pathophysiology of myocardial ischemia/reperfusion (I/R) injury. We hypothesized that in the late phase of hypertension with already developed signs of end-organ damage, inappropriate RAS activation could impair cardiac tolerance to I/R injury. Experiments were performed in male Cyp1a1-Ren-2 transgenic rats with inducible hypertension. The early phase of ANG II-dependent hypertension was induced by 5 days and the late phase by the 13 days dietary indole-3-carbinol (I3C) administration. Noninduced rats served as controls. Echocardiography and pressure-volume analysis were performed, angiotensins’ levels were measured and cardiac tolerance to ischemia/reperfusion injury was studied. The infarct size was significantly reduced (by 50%) in 13 days I3C-induced hypertensive rats with marked cardiac hypertrophy, this reduction was abolished by losartan treatment. In the late phase of hypertension there are indications of a failing heart, mainly in reduced preload recruitable stroke work (PRSW), but only nonsignificant trends in worsening of some other parameters, showing that the myocardium is in a compensated phase. The influence of the RAS depends on the balance between the vasoconstrictive and the opposed vasodilatory axis. In the initial stage of hypertension, the vasodilatory axis of the RAS prevails, and with the development of hypertension the vasoconstrictive axis of the RAS becomes stronger. We observed a clear effect of AT1 receptor blockade on maximum pressure in left ventricle, cardiac hypertrophy and ANG II levels. In conclusion, we confirmed improved cardiac tolerance to I/R injury in hypertensive hypertrophied rats and showed that, in the late phase of hypertension, the myocardium is in a compensated phase. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2024 Electronic address https://doi.org/10.3389/fphys.2023.1151308
Number of the records: 1