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Chitosan and cellulose-based composite hydrogels with embedded titanium dioxide nanoparticles as candidates for biomedical applications
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SYSNO ASEP 0573215 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Chitosan and cellulose-based composite hydrogels with embedded titanium dioxide nanoparticles as candidates for biomedical applications Author(s) Kasi, P. B. (CZ)
Azar, M. G. (CZ)
Dodda, J. M. (CZ)
Bělský, P. (CZ)
Kovářík, T. (CZ)
Šlouf, Miroslav (UMCH-V) RID, ORCID
Kolaja Dobrá, J. (CZ)
Babuška, V. (CZ)Article number 125334 Source Title International Journal of Biological Macromolecules. - : Elsevier - ISSN 0141-8130
Roč. 243, 15 July (2023)Number of pages 12 s. Language eng - English Country NL - Netherlands Keywords chitosan ; microcrystalline cellulose ; titanium dioxide Subject RIV CD - Macromolecular Chemistry OECD category Polymer science Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 UT WOS 001024573000001 EID SCOPUS 85161627395 DOI https://doi.org/10.1016/j.ijbiomac.2023.125334 Annotation Hydrogel based matrices and titanium dioxide (TiO2) nanoparticles (NPs) are well established materials in bone tissue engineering. Nevertheless, there is still a challenge to design appropriate composites with enhanced mechanical properties and improved cell growth. Progressing in this direction, we synthesized nanocomposite hydrogels by impregnating TiO2 NPs in a chitosan and cellulose-based hydrogel matrix containing polyvinyl alcohol (PVA), to enhance the mechanical stability and swelling capacity. Although, TiO2 has been incorporated into single and double component matrix systems, it has rarely been combined with a tri-component hydrogel matrix system. The doping of NPs was confirmed by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy and small- and wide-angle X-ray scattering. Our results showed that incorporation of TiO2 NPs improved the tensile properties of the hydrogels significantly. Furthermore, we performed biological evaluation of scaffolds, swelling degree, bioactivity assessment, and hemolytic tests to prove that all types of hydrogels were safe for use in the human body. The culturing of human osteoblast-like cells MG-63 on hydrogels showed better adhesion of cells in the presence of TiO2 and showed increasing proliferation with increasing amount of TiO2. Our results showed that the sample with the highest TiO2 concentration, CS/MC/PVA/TiO2 (1 %) had the best biological properties. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2024 Electronic address https://www.sciencedirect.com/science/article/pii/S0141813023022286?via%3Dihub
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