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Synthesis and anti-fouling properties of zwitterionic poly(L-glutamic acid)
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SYSNO ASEP 0573142 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis and anti-fouling properties of zwitterionic poly(L-glutamic acid) Author(s) Hladysh, Sviatoslav (UMCH-V) RID, ORCID
Dvořáková, Jana (UMCH-V) RID, ORCID
Proks, Vladimír (UMCH-V) RID, ORCIDSource Title Macromolecular Research - ISSN 1598-5032
Roč. 31, č. 6 (2023), s. 593-601Number of pages 9 s. Language eng - English Country KR - Korea, Republic of Keywords zwitterionic polymer ; poly(L-glutamic acid) ; anti-fouling Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects GA21-06524S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 UT WOS 000944096700001 EID SCOPUS 85149290139 DOI 10.1007/s13233-023-00145-6 Annotation Zwitterionic polymers are frequently used as non-fouling materials for surface modification with following application in medical devices, implants or areas of our lives such as food, water, and energy. Here, authors report the synthesis of zwitterionic poly(l-glutamic acid) copolymer bearing sulfobetaine via combining the ring-opening polymerization of N-carboxyanhydride of γ-benzyl-l-glutamate and grafting reaction of propargylamine, tyramine, and 3-(dimethylamino)-1-propylamine to the polymer backbone with subsequent reaction of 1,3-propanesultone leading to the formation of zwitterionic poly(l-glutamic acid) containing sulfobetaine groups. Zwitterionic properties of the copolymer are represented by positively charged quaternary ammonium groups and negatively charged sulfobetaine moieties. The chemical structure of the synthesized zwitterionic poly(l-glutamic acid) was characterized by 1H NMR, FTIR, and UV/Vis spectroscopy. The zwitterionic abilities of copolymer were confirmed by zeta potential measurements. The zeta potential of zwitterionic polymer decreased from + 15 mV to − 19 mV upon stepwise pH increases from 2 to 11. The surface properties such as hydrophilicity and non-fouling abilities were tested by contact angle analysis and surface plasmon resonance technique, respectively. The prepared material indicates the formation of highly hydrophilic surfaces with relatively low contact angle (26°) and remarkable anti-protein adsorption functions reflected in lower resonance wavelength shifts from SPR sensogram. Results of this work show the importance of the developed biodegradable zwitterionic poly(l-glutamic acid)-based coatings for applications in various biomedical fields. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2024 Electronic address https://link.springer.com/article/10.1007/s13233-023-00145-6
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