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Sex differences in blood pressure, free radicals and plasma cholesterol fractions in Ren-2 transgenic rats of various ages
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SYSNO ASEP 0573114 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Sex differences in blood pressure, free radicals and plasma cholesterol fractions in Ren-2 transgenic rats of various ages Author(s) Rauchová, Hana (FGU-C) RID, ORCID
Hojná, Silvie (FGU-C) RID, ORCID
Kadlecová, Michaela (FGU-C) RID
Vaněčková, Ivana (FGU-C) RID, ORCID
Chao, YM. (TW)
Chan, J. Y. H. (TW)
Zicha, Josef (FGU-C) RID, ORCID, SAISource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 72, č. 2 (2023), s. 167-175Number of pages 9 s. Language eng - English Country CZ - Czech Republic Keywords hypertension ; Thiobarbituric acid-reactive species (TBARS) ; reduced glutathione ; total plasma cholesterol ; HDL and LDL cholesterol fractions OECD category Cardiac and Cardiovascular systems R&D Projects GC19-08260J GA ČR - Czech Science Foundation (CSF) LX22NPO5104 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 001057117900004 EID SCOPUS 85158089434 DOI 10.33549/physiolres.935059 Annotation Sex-related cardiovascular differences were observed in humans as well as in experimental animals. Our previous study demonstrated a marked sexual dimorphism in blood pressure (BP) of 9-month-old heterozygous transgenic Ren 2 rats (TGR), in which mouse Ren-2 renin gene was inserted into the genome of normotensive Hannover Sprague-Dawley rats (HanSD). We found significantly elevated BP only in male TGR, whereas BP of TGR females was similar to that of HanSD females. The aim of our present study was to compare BP of 3- and 6-month-old heterozygous TGR with age- and sex-matched HanSD under the same conditions as we measured in 9-month-old rats. We also monitored the amount of oxidative stress marker, thiobarbituric acid-reactive substances (TBARS), and a main intracellular antioxidant, reduced glutathione in the heart, kidneys and liver. We also measured plasma triglycerides and cholesterol levels. We found an increased mean arterial pressure in both female and male 3-month-old TGR (172±17 vs. 187±4 mm Hg, respectively) compared to HanSD (115±5 vs. 133±3 mm Hg, respectively) but there was a marked sexual dimorphism of 6-month-old TGR where only males were hypertensive (145±5 mm Hg) while females became normotensive (123±7 mm Hg). We did not find any relationship between BP values and concentrations of TBARS or glutathione or plasma lipid levels. Our results demonstrated that 6-month-old TGR exhibited a marked sexual BP dimorphism, which was not dependent on the abnormalities in oxidative stress or cholesterol metabolism. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2024 Electronic address https://www.biomed.cas.cz/physiolres/pdf/2023/72_167.pdf
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